Distributed and retinotopically asymmetric processing of coherent motion in mouse visual cortex.

Nature Communications
Kevin K Sit, Michael J Goard

Abstract

Perception of visual motion is important for a range of ethological behaviors in mammals. In primates, specific visual cortical regions are specialized for processing of coherent visual motion. However, whether mouse visual cortex has a similar organization remains unclear, despite powerful genetic tools available for measuring population neural activity. Here, we use widefield and 2-photon calcium imaging of transgenic mice to measure mesoscale and cellular responses to coherent motion. Imaging of primary visual cortex (V1) and higher visual areas (HVAs) during presentation of natural movies and random dot kinematograms (RDKs) reveals varied responsiveness to coherent motion, with stronger responses in dorsal stream areas compared to ventral stream areas. Moreover, there is considerable anisotropy within visual areas, such that neurons representing the lower visual field are more responsive to coherent motion. These results indicate that processing of visual motion in mouse cortex is distributed heterogeneously both across and within visual areas.

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Citations

Jan 14, 2021·Cell Reports·Manavu TohmiJianhua Cang
Oct 16, 2020·Neuron·Jessica A CardinMichael J Higley
Jun 12, 2021·IScience·Mai M MorimotoAman B Saleem
Jul 1, 2021·Nature Communications·Enny H van BeestMatthew W Self
Apr 30, 2021·Annual Review of Neuroscience·Cristopher M Niell, Massimo Scanziani
Aug 29, 2021·Nature Communications·Tyler D Marks, Michael J Goard

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