Distributed Motor Control of Limb Movements in Rat Motor and Somatosensory Cortex: The Sensorimotor Amalgam Revisited.

Cerebral Cortex
Andrew C HalleyLeah Krubitzer

Abstract

Which areas of the neocortex are involved in the control of movement, and how is motor cortex organized across species? Recent studies using long-train intracortical microstimulation demonstrate that in addition to M1, movements can be elicited from somatosensory regions in multiple species. In the rat, M1 hindlimb and forelimb movement representations have long been thought to overlap with somatosensory representations of the hindlimb and forelimb in S1, forming a partial sensorimotor amalgam. Here we use long-train intracortical microstimulation to characterize the movements elicited across frontal and parietal cortex. We found that movements of the hindlimb, forelimb, and face can be elicited from both M1 and histologically defined S1 and that representations of limb movement types are different in these two areas. Stimulation of S1 generates retraction of the contralateral forelimb, while stimulation of M1 evokes forelimb elevation movements that are often bilateral, including a rostral region of digit grasping. Hindlimb movement representations include distinct regions of hip flexion and hindlimb retraction evoked from S1 and hip extension evoked from M1. Our data indicate that both S1 and M1 are involved in the generation...Continue Reading

References

Nov 20, 1982·The Journal of Comparative Neurology·J P Donoghue, S P Wise
Jan 28, 1982·Brain Research·E J Neafsey, C Sievert
Mar 4, 2000·The Journal of Comparative Neurology·E DisbrowL Krubitzer
Aug 1, 2002·Nature Neuroscience·Peter L Strick
Nov 1, 2002·Neuron·Michael S A GrazianoDylan F Cooke
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Dylan F CookeMichael S A Graziano
Jul 1, 1957·Journal of Neurophysiology·W I WELKERC N WOOLSEY
Dec 1, 1963·The Journal of Comparative Neurology·R A LENDE
Dec 1, 1963·The Journal of Comparative Neurology·R A LENDE
Mar 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Iwona StepniewskaJon H Kaas
Jul 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Dhakshin RamanathanMark H Tuszynski
Jan 5, 2008·The Journal of Comparative Neurology·Mark J BurishJon H Kaas
Jun 11, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Li-Yuan LiuJin Fang
Nov 27, 2010·Science·Ferenc MatyasCarl C H Petersen
Jun 28, 2011·Brain, Behavior and Evolution·Leah KrubitzerDylan F Cooke
Aug 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Omar A GharbawieJon H Kaas
Oct 25, 2011·Cerebral Cortex·Dylan F CookeLeah Krubitzer
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura BonazziGianfranco Franchi
Oct 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew R Brown, G Campbell Teskey
Dec 6, 2014·The European Journal of Neuroscience·Varun SreenivasanCarl C H Petersen
Apr 10, 2015·Journal of Neurophysiology·J E DeffeyesN Dancause
Oct 23, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dylan F CookeLeah Krubitzer
Apr 3, 2016·The Journal of Comparative Neurology·Hisham Mohammed, Neeraj Jain
Jun 21, 2016·Current Biology : CB·Adjia HamadjidaNuma Dancause
Apr 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jean-Alban RathelotPeter L Strick
Sep 12, 2018·Scientific Reports·Ann M ClemensMichael Brecht
Jan 19, 2019·Current Opinion in Neurobiology·Andrew C Halley, Leah Krubitzer
Jun 27, 2019·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrei MayerLeah Krubitzer
Nov 20, 2019·Nature Neuroscience·Spyridon K KaradimasMichael G Fehlings

❮ Previous
Next ❯

Citations

Feb 16, 2021·Progress in Neurobiology·Daniel H O'ConnorSliman Bensmaia
Jan 21, 2021·Journal of Neurophysiology·Anna C SingletonG Campbell Teskey
Aug 8, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Todd M Preuss, Steven P Wise

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.