Distributing tasks via multiple input pathways increases cellular survival in stress

ELife
Alejandro A GranadosPeter S Swain

Abstract

Improving in one aspect of a task can undermine performance in another, but how such opposing demands play out in single cells and impact on fitness is mostly unknown. Here we study budding yeast in dynamic environments of hyperosmotic stress and show how the corresponding signalling network increases cellular survival both by assigning the requirements of high response speed and high response accuracy to two separate input pathways and by having these pathways interact to converge on Hog1, a p38 MAP kinase. Cells with only the less accurate, reflex-like pathway are fitter in sudden stress, whereas cells with only the slow, more accurate pathway are fitter in increasing but fluctuating stress. Our results demonstrate that cellular signalling is vulnerable to trade-offs in performance, but that these trade-offs can be mitigated by assigning the opposing tasks to different signalling subnetworks. Such division of labour could function broadly within cellular signal transduction.

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Citations

Jun 20, 2020·FEMS Microbiology Reviews·Valentine Lagage, Stephan Uphoff
Oct 3, 2017·Bioinformatics·Elco BakkerMatthew M Crane
Nov 28, 2019·Physical Review. E·Takehiro TottoriShinya Kuroda
May 23, 2018·Proceedings of the National Academy of Sciences of the United States of America·Alejandro A GranadosPeter S Swain
Jul 14, 2019·Scientific Reports·Alexander ThiemickeGregor Neuert
May 20, 2020·Journal of Mathematical Biology·David S Tourigny
Jan 23, 2021·Journal of Mathematical Biology·David S Tourigny
Jan 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Amanda N JohnsonGregor Neuert
Jan 22, 2021·Physical Biology·Arvind MuruganNigel Goldenfeld
Dec 12, 2021·Critical Reviews in Microbiology·Hajar YaakoubNicolas Papon

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Methods Mentioned

BETA
fluorescence microscopy
PCR
fluorescence imaging

Software Mentioned

ALCATRAS
xcorr
Matlab
Simulink
Matlab code

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