Distribution and biomarkers of carbon-14-labeled fullerene C60 ([(14) C(U)]C60 ) in female rats and mice for up to 30 days after intravenous exposure

Journal of Applied Toxicology : JAT
Susan C J SumnerTimothy R Fennell

Abstract

A comprehensive distribution study was conducted in female rats and mice exposed to a suspension of uniformly carbon-14-labeled C60 ([(14) C(U)]C60 ). Rodents were administered [(14) C(U)]C60 (~0.9 mg kg(-1) body weight) or 5% polyvinylpyrrolidone-saline vehicle alone via a single tail vein injection. Tissues were collected at 1 h and 1, 7, 14 and 30 days after administration. A separate group of rodents received five daily injections of suspensions of either [(14) C(U)]C60 or vehicle with tissue collection 14 days post exposure. Radioactivity was detected in over 20 tissues at all time points. The highest concentration of radioactivity in rodents at each time point was in liver, lungs and spleen. Elimination of [(14) C(U)]C60 was < 2% in urine and feces at any 24 h time points. [(14) C(U)]C60 and [(14) C(U)]C60 -retinol were detected in liver of rats and together accounted for ~99% and ~56% of the total recovered at 1 and 30 days postexposure, respectively. The blood radioactivity at 1 h after [(14) C(U)]C60 exposure was fourfold higher in rats than in mice; blood radioactivity was still in circulation at 30 days post [(14) C(U)]C60 exposure in both species (<1%). Levels of oxidative stress markers increased by 5 days after ex...Continue Reading

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Citations

Jul 21, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kelly MercierSusan Sumner
Sep 17, 2015·Toxicology and Applied Pharmacology·P A StapletonT R Nurkiewicz
Jul 18, 2019·Digestive Diseases and Sciences·Halyna M KuznietsovaUwe Ritter
Dec 29, 2020·Nanotoxicology·Dayene de Assis Fernandes CaldeiraWalter Araujo Zin
Nov 27, 2019·Nano-micro Letters·Xinhong LiYafei Zhang
Sep 28, 2021·Journal of Applied Toxicology : JAT·Ninell P MortensenTimothy R Fennell

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