PMID: 7336962Jul 1, 1981Paper

Distribution and biotransformation of methyl mercuric chloride in different tissues of mice

Acta Pharmacologica Et Toxicologica
M Mehra, B H Choi

Abstract

The distribution of 203Hg radioactivity has been studied in various organs of adult male and female mice from one hour to 21 days after treating with 203 Hg-labeled methyl mercuric chloride (MMC). The amount of methyl mercury (MeHg) and inorganic mercury (Hg) has also been determined by injecting single doses of non-radioactive MMC, and subsequently measuring total, organic and inorganic Hg content by atomic absorption technique. In addition, photoemulsion histochemical method (PEHM) was used to demonstrate localization of Hg grains in various cellular compartments of organs and tissues. The highest levels of radioactivity were attained at 7 hours post-treatment in all organs except for brain and testis. The testis showed the highest radioactivity at one day and the brain at two days post-treatment. MeHg persisted in brain over a longer period though the level was not as high. The content of MeHg and inorganic Hg was maximum in kidneys as compared to other organs. The brain and the reproductive organs contained the least amount of inorganic Hg. By PEHM, Hg grains were most prominently observed in the sinusoids, Kupfer cells, hepatic cells and bile duct epithelium of liver; in the lumen of blood vessels, convoluted and collectin...Continue Reading

References

Jul 3, 1978·Life Sciences·M G Cherian, R A Goyer
Apr 1, 1979·Bulletin of Environmental Contamination and Toxicology·M Mehra, K C Kanwar
Feb 1, 1977·Toxicology and Applied Pharmacology·J S MacDonald, R D Harbison
Apr 1, 1976·Toxicology and Applied Pharmacology·H R BerthoudB Weiss
Jul 1, 1972·Journal of Neuropathology and Experimental Neurology·L W ChangH A Hartmann
Jul 20, 1973·Science·F BakirR A Doherty
Dec 1, 1970·Archives of Environmental Health·T Norseth, T W Clarkson
May 1, 1971·Archives of Environmental Health·T Norseth, T W Clarkson
Apr 1, 1980·Bulletin of Environmental Contamination and Toxicology·M Mehra, K C Kanwar

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Citations

Jul 20, 2016·The Journal of Toxicological Sciences·Takuya UchikawaHideyuki Yamada
Jan 1, 1988·Acta Neuropathologica·B H ChoiN H Peckham
Nov 1, 1986·Archives of Environmental Contamination and Toxicology·M Aihara, R P Sharma
Nov 1, 1990·Bulletin of Environmental Contamination and Toxicology·A Yasutake, K Hirayama

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