Distribution and categorization of left ventricular measurements in the general population: results from the population-based Gutenberg Heart Study

Circulation. Cardiovascular Imaging
Philipp S WildStefan Blankenberg

Abstract

Echocardiography, the dominant imaging modality for quantification of left ventricular metrics, has undergone continuing development in the past few decades. However, given the lack of population-based data, current guidelines are still based on restricted and small data sets analyzed with methods including expert opinion. This work presents empirically derived reference values from a large-scale, epidemiologic study conducted with state-of-the-art imaging technology and methods. The distribution of echocardiographic measurements of the left ventricle was analyzed in a population-based sample of 5000 mid-Europeans from the Gutenberg Heart Study in Germany. The randomly selected, noninstitutionalized sample provides data on apparently healthy individuals, as well as on those with prevalent disease. Standardized echocardiograms were recorded in a comprehensive data set at a single site with centralized training and certification of sonographers. Sex-specific reference limits and categories indicating the grade of deviation from the reference were calculated, and nomograms were created by quantile regression. Detailed information is given on the association between left ventricular geometry and age. The rapidly evolving echocardio...Continue Reading

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Citations

Jun 28, 2012·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·P S WildS Blankenberg
Apr 24, 2013·Current Hypertension Reports·Michele BombelliGiuseppe Mancia
Nov 26, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christoph SinningUNKNOWN Gutenberg Health Study
Nov 10, 2013·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Cesare CuspidiGiuseppe Schillaci
Apr 15, 2014·European Heart Journal·Tanja ZellerStefan Blankenberg
Oct 7, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Andrea BarbieriMaria Grazia Modena
May 20, 2015·International Archives of Occupational and Environmental Health·Susan Garthus-NiegelAndreas Seidler
Apr 13, 2011·The American Journal of Cardiology·Christoph SinningUNKNOWN Gutenberg-Heart Study
Dec 31, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Danuta GaletzkaThomas Haaf
May 31, 2016·International Journal of Cardiology·Christina BaumUNKNOWN Gutenberg Health Study investigators
Nov 14, 2016·International Journal of Cardiology·Christoph SinningDirk Westermann
Dec 15, 2015·Frontiers in Cardiovascular Medicine·Renate B SchnabelUNKNOWN Gutenberg Health Study Investigators
Oct 25, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Susanne KarbachThomas Münzel
Apr 13, 2012·Journal of Hypertension·Cesare CuspidiGiuseppe Mancia
Mar 31, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Davit ManukyanKarl J Lackner
Jun 14, 2017·BMC Cardiovascular Disorders·Olga V PattersonScott L DuVall
Jun 17, 2020·Journal of Occupational Medicine and Toxicology·Karla Romero StarkeAndreas Seidler
Mar 2, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Teresa TrenkwalderRenate Schnabel
Dec 23, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christoph SinningTanja Zeller
Jun 15, 2017·BMC Medical Research Methodology·Andreas SchulzHarald Binder
Oct 16, 2020·Haematologica·Pauline C S van ParidonHenri M H Spronk

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