PMID: 12773127May 30, 2003Paper

Distribution and changes in amounts of the androgen receptor in the pig uterus during the estrous cycle, early pregnancy and after treatment with sex steroids

The Journal of Endocrinology
H Cárdenas, William F Pope

Abstract

Two experiments were performed to examine the expression of the androgen receptor (AR) gene in the pig uterus. In experiment 1, immunohistochemistry (IHC) was used to determine the distribution of the AR in uterine tIssue of pigs when collected at the first day of estrus (day 0) and the mid-luteal phase (day 12) of the estrous cycle, or early pregnancy (day 12, n=4 gilts per group). In experiment 2, AR immunostaining and AR mRNA in uterine tIssue were compared among ovariectomized gilts (n=4 per group) following treatment for 4 days with daily injections of: (1) progesterone (2 mg/kg bodyweight (BW)), (2) estradiol-17beta (E(2,) 2 micro g/kg BW), (3) E(2) plus progesterone (same dosages as 1 and 2 combined), (4) 5alpha-dihydrotestosterone (DHT, 7 micro g/kg BW), or (5) vehicle (corn oil). Data were analyzed using ANOVA. In experiment 1, nuclear staining for AR in luminal and glandular epithelia was strong and did not differ in intensity between the two locations. Immunostaining of AR in the myometrium was less (P<0.001) intense than in the luminal and glandular epithelia. Nuclei of stromal cells contained AR immunostaining that varied in intensity from strong (mainly in subepithelial stroma) to weak or no staining. Stages of th...Continue Reading

Citations

Jan 9, 2004·Biology of Reproduction·Andrés A KowalskiRosalia C M Simmen
Sep 23, 2014·Functional & Integrative Genomics·Anita FranczakGenowefa Kotwica
Aug 1, 2015·Molecular Reproduction and Development·Jingjie XuHaibin Kuang
Jul 1, 2008·Transplantation Proceedings·G CastroA Cabrita
Jan 18, 2008·Reproduction in Domestic Animals = Zuchthygiene·M SłomczyńskaM Koziorowski

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