Distribution and density of contacts from noradrenergic and serotonergic boutons on the dendrites of neck flexor motoneurons in the adult cat

The Journal of Comparative Neurology
Robert MarattaP Ken Rose

Abstract

Serotonergic (5-HT) and noradrenergic (NA) input to spinal motoneurons is essential for generating plateau potentials and self-sustained discharges. Extensor motoneurons are densely innervated by 5-HT and NA synapses and have robust plateau potentials and self-sustained discharges. Conversely, plateau potentials and self-sustained discharges are very rare in flexor motoneurons. The most likely reasons for this difference are that flexor motoneurons have few 5-HT and NA synapses and/or they are distributed distant to the channels responsible for plateau potentials and self-sustained discharges. However, the distribution of 5-HT and NA synapses on flexor motoneurons is unknown. Here we describe the distribution and density of 5-HT and NA synapses on motoneurons that innervate the flexor neck muscle, rectus capitis anterior (RCA), in the adult cat. Using a combination of intracellular staining, fluorescent immunohistochemistry, and 3D reconstruction techniques, we found that 5-HT and NA synapses are widely distributed throughout the dendritic trees of RCA motoneurons, albeit with a strong bias to small-diameter dendrites and to medial dendrites in the case of NA contacts. The number of 5-HT and NA contacts per motoneuron ranged, r...Continue Reading

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Citations

Nov 20, 2016·The Journal of Physiology·Jessica M D'AmicoJanet L Taylor
Jan 6, 2017·Journal of Neurophysiology·Randall K Powers, Charles J Heckman
Dec 13, 2018·Physiology·Marin ManuelC J Heckman
Oct 27, 2017·Journal of Neurophysiology·C Jean-XavierP J Whelan
Jul 16, 2020·Journal of Neurophysiology·Edward H KimCharles J Heckman
Mar 20, 2015·Journal of Neurophysiology·Jessica M WilsonCharles J Heckman
Jan 16, 2021·The Journal of Physiology·Adam S DeardorffRobert E W Fyffe
Feb 19, 2021·Journal of Neurophysiology·Jacob R ThorstensenJustin J Kavanagh
Jun 10, 2021·Journal of Neurophysiology·Tea Lulic-KurylloClark R Dickerson

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