PMID: 9663916Jul 15, 1998Paper

Distribution and determinants of cardiovascular events during 20 years of successful antihypertensive treatment

Journal of Hypertension
M H AldermanS Madhavan

Abstract

To define the distribution and determinants of cardiovascular disease events among participants undergoing long-term antihypertensive therapy, and to stratify them into risk groups on the basis of pretreatment clinical profiles. A prospective cohort study of participants in a worksite-based antihypertensive treatment program in New York city (1973-1994). We studied 8690 systematically treated patients who had at least 6 months of follow-up (average of 5.7 years) and, at entry, had had a systolic blood pressure of > or = 160 mmHg or a diastolic blood pressure of > or = 95 mmHg (after 1992 > or = 140/90 mmHg), or had been being administered antihypertensive medication. Blood pressure and incidence of morbid and mortal cardiovascular events. Blood pressure control (to 140 +/- 3/87 +/- 7 mmHg) was achieved by the first year and maintained through 18 years of therapy. In nearly 50,000 person-years of follow-up, there were 468 cardiovascular disease events [myocardial infarction including revascularization (282), strokes (93), congestive heart failure (30) and other cardiovascular deaths (63)]. Deaths from cardiovascular disease events accounted for 68% of all deaths. Myocardial infarction was most common throughout, but congestive h...Continue Reading

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Citations

Sep 6, 2005·Cardiovascular Drugs and Therapy·Larus S GudmundssonJacqueline C M Witteman
May 7, 2004·Current Hypertension Reports·Michel E Safar
Aug 3, 2005·Current Hypertension Reports·Raymond R Townsend
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