Distribution and elimination of fumonisin analogues in weaned piglets after oral administration of Fusarium verticillioides fungal culture

Food Additives and Contaminants
J FodorM Kovacs

Abstract

The distribution and elimination of fumonisins after oral administration of 50 mg FB(1), 20 mg FB(2) and 5 mg FB(3) per animal day(-1) for 22 days was studied in weaned barrows. At the end of the trial, the lung, heart, liver, kidney, spleen, brain, serum, bile, muscle, fat, urine and faeces samples were collected and their content of fumonisins (FB(1), FB(2)) determined by LC-MS. The highest FB(1) concentrations were found in the liver (99.4 +/- 37.5 ng g(-1)) and kidneys (30.6 +/- 10.1 ng g(-1)), whilst the highest average amount of FB(2) was in the liver (1.4 +/- 2.3 ng g(-1)) and fat (2.6 ng g(-1) +/- 4.8) samples. Comparing the FB(1)/FB(2) ratio in different organs (19/1), it was found that the ratio in the abdominal and subcutaneous fat samples (4/1) was markedly different from those in all other tissues, namely the relative proportion of FB(2) was higher in latter cases. Of the total quantity of FB(1), the 13% taken up during 5 days was excreted unchanged with the faeces and urine. On average, in the urine and faeces, FB(1) was detected in nine- and 14-fold quantities, as compared with FB(2).

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Citations

Apr 25, 2007·Food Additives and Contaminants·Judit FodorMelinda Kovacs
Feb 23, 2011·Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional·G Cano-SanchoV Sanchis
Jul 21, 2007·Molecular Nutrition & Food Research·Sandrine Bouhet, Isabelle P Oswald
Aug 23, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·András SzabóMelinda Kovács
Nov 29, 2007·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·J FodorM Kovács
Nov 23, 2018·Frontiers in Microbiology·Tobias BauerMonika Ehling-Schulz
May 25, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Isabelle P Oswald
Feb 23, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Jan Alexander
Jan 27, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Liana van der WesthuizenYun Yun Gong
Feb 1, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wim SchelstraeteSiska Croubels
Aug 27, 2021·Toxins·Agnieszka Tkaczyk, Piotr Jedziniak

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