PMID: 7714711Dec 1, 1994

Distribution and elimination of sulphadimethoxine and its metabolites in treated chicken

The Journal of Pharmacy and Pharmacology
T Nagata, Y Fukuda

Abstract

Sulphadimethoxine (SDM), and its metabolites, N4-acetyl SDM, N1-(2-methyl-6-hydroxy-4-pyrimidinyl) sulphanilamide (6-OH-SDM), N1-(6-methyl-2-hydroxy-4-pyrimidinyl) sulphanilamide (2-OH-SDM), N1-(2,6-dihydroxy-4-pyrimidinyl) sulphanilamide (2,6-diOH-SDM) and SDM N1-glucuronide in chicken tissues were extracted, partially purified by Bond Elute SCX cartridges, and assayed and identified by HPLC/LC-MS after administration of SDM to chickens. During the administration and 24 h after withdrawal, SDM and 6-OH-SDM were observed in almost all tissues and excreta. N4-Acetyl SDM and 2,6-diOH-SDM were observed in some tissues, but 2-OH-SDM and SDM N1-glucuronide were observed in a few limited tissues. Twenty four hours after withdrawal, SDM and its metabolites, except 6-OH-SDM, decreased. SDM and its metabolites were eliminated from all tissues within 48 h of withdrawal.

References

Oct 1, 1986·Nihon juigaku zasshi. The Japanese journal of veterinary science·Y Takahashi
Jan 1, 1985·The Veterinary Quarterly·J F NouwsY A Hekster
Feb 1, 1986·Nihon juigaku zasshi. The Japanese journal of veterinary science·Y Takahashi
Oct 1, 1968·The Biochemical Journal·J W BridgesR T Williams
Jun 1, 1970·The Biochemical Journal·R H AdamsonR T Williams
Dec 1, 1970·Nihon juigaku zasshi. The Japanese journal of veterinary science·T OnoderaY Oshima
Sep 1, 1965·The Biochemical Journal·J W BridgesR T Williams
Apr 27, 1984·Pharmaceutisch Weekblad. Scientific Edition·T B VreeY A Hekster

Citations

Sep 1, 1996·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P E AdamsG D Paulson
Aug 5, 2018·Journal of Veterinary Pharmacology and Therapeutics·Trishna PatelLisa A Tell

Related Concepts

N(4)-acetylsulfadimethoxine
High Pressure Liquid Chromatography Procedure
Liquid Chromatography
Gastrointestinal System
Drug Residues
Gallbladder
Kidney
Liver
Lung
Muscle

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.