Distribution and evolution of the serine/aspartate racemase family in invertebrates

Amino Acids
Kouji UdaLuke A Moe

Abstract

Free D-amino acids have been found in various invertebrate phyla, while amino acid racemase genes have been identified in few species. The purpose of this study is to elucidate the distribution, function, and evolution of amino acid racemases in invertebrate animals. We searched the GenBank databases, and found 11 homologous serine racemase genes from eight species in eight different invertebrate phyla. The cloned genes were identified based on their maximum activity as Acropora millepora (Cnidaria) serine racemase (SerR) and aspartate racemase (AspR), Caenorhabditis elegans (Nematoda) SerR, Capitella teleta (Annelida) SerR, Crassostrea gigas (Mollusca) SerR and AspR, Dugesia japonica (Platyhelminthes) SerR, Milnesium tardigradum (Tardigrada) SerR, Penaeus monodon (Arthropoda) SerR and AspR and Strongylocentrotus purpuratus (Echinodermata) AspR. We found that Acropora, Aplysia, Capitella, Crassostrea and Penaeus had two amino acid racemase paralogous genes and these paralogous genes have evolved independently by gene duplication at their recent ancestral species. The transcriptome analyses using available SRA data and enzyme kinetic data suggested that these paralogous genes are expressed in different tissues and have different...Continue Reading

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Citations

Jul 9, 2016·Journal of Biochemistry·Tomokazu ItoHisashi Mori
Sep 4, 2019·Bioscience, Biotechnology, and Biochemistry·Kimihiko ShibataYoshio Kera
May 10, 2018·Frontiers in Microbiology·Tomokazu ItoTohru Yoshimura
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Feb 12, 2020·Applied Microbiology and Biotechnology·Shouji Takahashi
Feb 21, 2021·Journal of Inorganic Biochemistry·Joanna WątłyMagdalena Rowińska-Żyrek
Mar 13, 2021·The Biochemical Journal·Herman Wolosker, Inna Radzishevsky

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