Distribution and excretion of 2,3,6,2',3',6'- and 2,4,5,2',4',5'-hexachlorobiphenyl in senescent rats

Toxicology and Applied Pharmacology
L S Birnbaum

Abstract

The disposition of two symmetrical [14C]hexachlorobiphenyls (HCBs), 2,3,6,2',3',6'-HCB (236) and 2,4,5,2',4',5'-HCB (245), was studied in 24-month-old male Sprague-Dawley rats after iv treatment. Because body composition changes with age, complete dissections were performed on all rats to determine the size of the skin and adipose tissue depots. More than 50% of 236 was metabolized and excreted via the bile into the feces within 2 days. In contrast, 245 redistributed from the liver, muscle, and skin to adipose tissue where it accumulated without being metabolized. Only 2% of the total dose of 245 was excreted primarily in the feces within 21 days. The data obtained in this study were compared to results previously obtained from 2- to 3-month-old rats in this laboratory (Matthews and Tuey, 1980, Toxicol. Appl. Pharmacol. 53, 377-388). Although the general pattern of HCB disposition did not change with age, i.e., metabolism and excretion of 236 versus persistence of 245, there were differences in the rates of elimination and in the tissue levels. There was enhanced metabolite retention in the muscle, skin, and adipose tissue of older animals which suggested an age-related decrease in tissue clearance. The large volume of adipose ...Continue Reading

References

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May 1, 1980·Toxicology and Applied Pharmacology·H B Matthews, D B Tuey
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Sep 15, 1980·Toxicology and Applied Pharmacology·L S BirnbaumH B Matthews

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Citations

Apr 26, 2008·Archives of Environmental Contamination and Toxicology·Izabela Kania-KorwelHans-Joachim Lehmler
May 31, 1985·Mechanisms of Ageing and Development·M Lyte, P H Bick
Apr 16, 2013·Environmental Science & Technology·Xin HuPeter S Thorne
Apr 14, 2010·Environmental Science & Technology·Izabela Kania-KorwelHans-Joachim Lehmler
Sep 1, 1985·Environmental Health Perspectives·L S Birnbaum
Jan 30, 2015·Critical Reviews in Toxicology·Fabian A GrimmLarry W Robertson
Apr 1, 2015·Environmental Science and Pollution Research International·Izabela Kania-Korwel, Hans-Joachim Lehmler
Oct 31, 2015·Annual Review of Pharmacology and Toxicology·Linda S Birnbaum
Nov 28, 2013·Environment International·Xin HuPeter S Thorne
Aug 1, 1989·Journal of Pharmacokinetics and Biopharmaceutics·W W Piegorsch, A J Bailer
Oct 18, 2002·Nurse Education Today·Sally Glen
Jan 1, 1987·Journal of the American Geriatrics Society·L S Birnbaum
Oct 24, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I Kania-KorwelH-J Lehmler
Oct 1, 1996·Human & Experimental Toxicology·P W van Vliet, J de Jongh
Jun 1, 1994·Environmental Health Perspectives·S SoontornchatL G Hansen
Jul 15, 2015·Environmental Science and Pollution Research International·Xianai Wu, Hans-Joachim Lehmler
Feb 6, 2015·Environmental Science and Pollution Research International·Izabela Kania-Korwel, Hans-Joachim Lehmler
Nov 25, 2014·Environmental Science & Technology·Xianai WuHans-Joachim Lehmler
Mar 6, 2003·Journal of Agricultural and Food Chemistry·Yoko Nakashima, Sachie Ikegami
Nov 26, 2009·Pharmacology & Therapeutics·Isaac N PessahPamela J Lein

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