Distribution and functional organization of glomeruli in the olfactory bulbs of zebrafish (Danio rerio)

The Journal of Comparative Neurology
Oliver R BraubachRoger P Croll

Abstract

Odor molecules are transduced by thousands of olfactory sensory neurons (OSNs) located in the nasal cavity. Each OSN expresses a single functional odorant receptor protein and projects an axon from the sensory epithelia to an olfactory bulb glomerulus, which is selectively innervated by only one or a few OSN types. We used whole-mount immunocytochemistry to study the neurochemistry and anatomical organization of glomeruli in the zebrafish olfactory system. By employing combinations of antibodies against G-protein α subunits, calcium-binding proteins, and general neuronal markers, we selectively labeled various OSN types, their axonal projections to glomeruli, and the detailed anatomical distributions of individual glomeruli in different regions of the olfactory bulb. In this way we identified ≈140 glomeruli in each olfactory bulb of mature zebrafish. A small subset (27) of these glomeruli was unambiguously identifiable in nearly all animals examined. These units were large and, located mainly in the medial olfactory bulbs. Most glomeruli, however, were comparatively small, anatomically indistinguishable, and located in coarsely circumscribed regions; almost all of these latter glomeruli were innervated by OSNs that were labeled...Continue Reading

References

Jun 15, 1979·The Journal of Comparative Neurology·W B StewartG M Shepherd
Oct 22, 1992·The Journal of Comparative Neurology·D R Riddle, B Oakley
Jul 1, 1982·Brain Research Bulletin·N HalászM Goldstein
Jan 1, 1997·Annual Review of Neuroscience·J G Hildebrand, G M Shepherd
Jan 8, 1999·Microscopy Research and Technique·E Meisami, K P Bhatnagar
Mar 31, 1999·The Journal of Comparative Neurology·P P LaissueR F Stocker
Apr 23, 1999·The Journal of Comparative Neurology·H J KasowskiC A Greer
Aug 16, 2000·Cell·L B VosshallR Axel
Nov 18, 2000·Cell and Tissue Research·L P Nezlin, D Schild
Jul 5, 2001·The Journal of Comparative Neurology·M L SchaeferD Restrepo
Mar 22, 2002·The European Journal of Neuroscience·Arzu CelikS I Korsching
Mar 23, 2002·Current Biology : CB·Holger KnautChristiane Nüsslein-Volhard
May 15, 2002·Chemical Senses·El Hassan Hamdani, Kjell B Døving
Aug 6, 2003·The Journal of Comparative Neurology·Leonid P NezlinWolfgang Rössler
Aug 20, 2003·The Journal of Comparative Neurology·Andrea FrontiniBarbara S Zielinski
Jun 5, 2004·Science·Dong-Jing ZouStuart Firestein
Aug 27, 2004·The Journal of Comparative Neurology·Anne HansenThomas E Finger
Nov 4, 2004·Trends in Genetics : TIG·Shou SerizawaHitoshi Sakano
Mar 2, 2005·Chemical Senses·Anne HansenThomas E Finger
May 20, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuki SatoYoshihiro Yoshihara
Jun 17, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jun LiRainer W Friedrich
Dec 8, 2005·BMC Genomics·Tyler S Alioto, John Ngai
Mar 21, 2006·Nature Neuroscience·Mariel A Kerr, Leonardo Belluscio
Apr 8, 2006·Physiological Reviews·Kensaku MoriMasahiro Yamaguchi

❮ Previous
Next ❯

Citations

Mar 9, 2013·Molecules and Cells·Anders Enjin, Greg Seong-Bae Suh
Jun 4, 2013·Annual Review of Neuroscience·Rainer W Friedrich
Mar 29, 2014·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Valentina ParisiAntonino Germanà
Apr 15, 2014·Trends in Neurosciences·Adam Michael StewartAllan V Kalueff
Apr 10, 2014·Nature Communications·Nobuhiko MiyasakaYoshihiro Yoshihara
Oct 1, 2014·Communicative & Integrative Biology·Gaurav Ahuja, Sigrun Korsching
Jun 26, 2013·Scientific Reports·Gaurav AhujaSigrun I Korsching
Jan 9, 2013·The Journal of Comparative Neurology·Patricia GrañaJulián Yáñez
Jun 26, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Kathleen E Whitlock
Oct 30, 2013·Journal of Anatomy·Maurizio LazzariValeria Franceschini
Jul 16, 2013·The Journal of Comparative Neurology·Cecilia M NewtonFrank M Smith
Feb 26, 2015·The Journal of Comparative Neurology·Matthew R StoyekFrank M Smith
Mar 2, 2016·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Livia D'AngeloPaolo de Girolamo
Sep 27, 2012·Mechanisms of Development·Nobuhiko MiyasakaRainer W Friedrich
Mar 7, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Allan V KalueffAdam Michael Stewart
Apr 19, 2016·Nature Neuroscience·Adrian A WannerRainer W Friedrich
May 31, 2016·Nature Neuroscience·Yoichi YabukiYoshihiro Yoshihara
Sep 3, 2016·International Journal of Molecular Sciences·James T Hentig, Christine A Byrd-Jacobs
Apr 19, 2016·Scientific Reports·Daniela BiechlMario F Wullimann
Feb 11, 2014·Scientific Reports·Gaurav AhujaSigrun I Korsching
Dec 20, 2016·Aquatic Toxicology·Maurizio LazzariValeria Franceschini
Oct 23, 2018·Journal of Fish Biology·Caio MaximinoMonica Lima-Maximino
Feb 23, 2020·The Journal of Comparative Neurology·Lukas WeissIvan Manzini
Apr 21, 2020·PLoS Biology·Florence KermenEmre Yaksi
Apr 17, 2019·International Journal of Molecular Sciences·Erika Calvo-Ochoa, Christine A Byrd-Jacobs
Aug 22, 2018·Frontiers in Physiology·Brian Key, Deborah Brown
Sep 15, 2018·Journal of Bioenergetics and Biomembranes·Joanna M PozzutoChristine A Byrd-Jacobs
Aug 15, 2020·Frontiers in Neuroanatomy·Lukas WeissIvan Manzini
Mar 16, 2017·Scientific Reports·Daniela BiechlMario F Wullimann
Sep 21, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Suresh JesuthasanAjay Mathuru
Jan 8, 2021·Journal of Fish Biology·Melina Coelho da SilvaDavid Manuel Flores Gonçalves
Jan 31, 2021·Cell and Tissue Research·Gabriele Gerlach, Mario F Wullimann
May 16, 2017·Current Biology : CB·Noriko WakisakaYoshihiro Yoshihara

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