PMID: 9553751Apr 29, 1998Paper

Distribution and functional significance of angiotensin-II AT1- and AT2-receptor subtypes in the rat adrenal gland

Endocrine Research
A S BelloniG G Nussdorfer

Abstract

The distribution and the functional significance of angiotensin-II (ANG-II) receptor subtypes, AT1 and AT2, in the rat adrenal gland has been investigated in vitro. Autoradiographic assessment of the selective displacement of [125I]ANG-II binding by selective ligands of the two receptor subtypes indicated that zona glomerulosa (ZG) was provided with both AT1 and AT2, and adrenal medulla (AM) almost exclusively with AT2 receptors. ANG-II (10(-9) M) evoked a marked rise in the secretion of aldosterone by dispersed ZG cells and catecholamines by AM fragments. The selective AT1-receptor antagonist DuP753 blocked aldosterone response to ANG-II, while the selective AT2-receptor antagonist PD123319 was ineffective. Catecholamine response to ANG-II was inhibited by PD123319 and only moderately affected by high concentrations of DuP753. The selective AT2-receptor agonist CGP42112 did not change basal aldosterone release of ZG cells, but concentration-dependently enhanced basal catecholamine release by AM fragments. In light of these findings the conclusion is drawn that in the rat the aldosterone secretagogue effect of ANG-II is exclusively mediated by the AT1 receptors present in the ZG, while the catecholamine secretagogue action prem...Continue Reading

References

Oct 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·R OualiJ M Saez
Jun 1, 1992·Hypertension·J H LudensD W DuCharme
Jan 1, 1990·Journal of Cardiovascular Pharmacology·M de GasparoB Kamber
Nov 30, 1989·Biochemical and Biophysical Research Communications·A T ChiuA L Johnson
Aug 30, 1989·Biochemical and Biophysical Research Communications·S WhitebreadM de Gasparo
Jul 1, 1985·Regulatory Peptides·A IsraelJ M Saavedra
Sep 1, 1966·Circulation Research·M J PeachD T Watts
Apr 17, 1995·Brain Research·F M Heemskerk, J M Saavedra
Jul 1, 1995·Trends in Pharmacological Sciences·C Nahmias, A D Strosberg
Jul 1, 1994·The Journal of Endocrinology·D G ButlerG Y Oudit
Aug 1, 1994·Endocrinology·J LaredoJ M Hamlyn
Feb 1, 1996·Endocrinology·P A DorisD M Stocco
Nov 1, 1996·Endocrine Research·L BreaultN Gallo-Payet
Apr 1, 1997·The Journal of Clinical Endocrinology and Metabolism·P G AndreisG G Nussdorfer

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Citations

Aug 30, 2008·Science in China. Series C, Life Sciences·X ZhangW Zhang
Jun 15, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jinzhi OuyangXu Zhang
Oct 16, 2001·Regulatory Peptides·J M SaavedraT Inagami
Jan 7, 1999·The Journal of Steroid Biochemistry and Molecular Biology·L K MalendowiczK W Nowak
Sep 17, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·David Z I CherneyHeather N Reich
Mar 17, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Keita HaradaMasumi Inoue
Nov 29, 2005·Metabolism: Clinical and Experimental·Martin S MuntzelOnyekwere Onwumere
Oct 1, 2011·Hormone Molecular Biology and Clinical Investigation·Greti Aguilera
Dec 4, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Li YuLie Gao
Apr 17, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B PetersJ Peters
May 28, 2003·Microscopy Research and Technique·G P Vinson
Nov 23, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Maritza P GarridoAlfonso H Paredes
Mar 1, 2001·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Ines ArmandoJuan M Saavedra
Nov 20, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karine BibeauMichèle Brochu
Feb 10, 2012·American Journal of Physiology. Endocrinology and Metabolism·Barbara PetersSigrid C Hoffmann
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R H WorckJ S Petersen

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