Distribution and impact of yeast thermal tolerance permissive for mammalian infection

BMC Biology
Vincent RobertArturo Casadevall

Abstract

From the viewpoint of fungal virulence in mammals, thermal tolerance can be defined as the ability to grow in the 35°C to 40°C range, which is essential for inhabiting these hosts. We used archival information in a fungal collection to analyze the relationship between thermal tolerance and genetic background for over 4,289 yeast strains belonging to 1,054 species. Fungal genetic relationships were inferred from hierarchical trees based on pairwise alignments using the rRNA internal transcribed spacer and large subunit rDNA (LSU) sequences. In addition, we searched for correlations between thermal tolerance and other archival information including antifungal susceptibility, carbon sources, and fermentative capacity. Thermal tolerance for growth at mammalian temperatures was not monophyletic, with thermally tolerant species being interspersed among families that include closely related species that are not thermal tolerant. Thermal tolerance and resistance to antifungal drugs were not correlated, suggesting that these two properties evolved independently. Nevertheless, the ability to grow at higher temperatures did correlate with origin from lower geographic latitudes, capacity for fermentation and assimilation of certain carbon ...Continue Reading

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Citations

Mar 27, 2018·Yeast·Pietro BuzziniAndrey Yurkov
Sep 26, 2019·Anais Da Academia Brasileira De Ciências·Xênia M SoutoAndré L S Santos
Oct 3, 2019·World Journal of Microbiology & Biotechnology·Florian M FreimoserQuirico Migheli
Jul 25, 2019·MBio·Arturo CasadevallVincent Robert
Mar 31, 2018·MSphere·Thomas A AuchtungJoseph F Petrosino
Apr 17, 2020·IScience·Alejandra Rodríguez-VerdugoPamela Yeh

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