Distribution and inducibility of cytosolic epoxide hydrolase in male Sprague-Dawley rats

Biochemical Pharmacology
L SchladtF Oesch

Abstract

Cytosolic epoxide hydrolase (cEH) activity has been determined in liver and various extrahepatic tissues of male Sprague-Dawley rats using trans-stilbene oxide (TSO) and trans-ethylstyrene oxide (TESO) as substrates. Large interindividual differences in the specific activity of cytosolic epoxide hydrolase in the liver from more than 80 individual rats were observed varying by a factor of 38. In a randomly selected group of five animals liver cEH varied by a factor of 3.9 and kidney cEH by a factor of 2.7, whereas liver microsomal epoxide hydrolase and lactate dehydrogenase showed only very low variations (1.4- and 1.1-fold, respectively). The individual relative activity of kidney cEH was related to that of the liver. Cytosolic epoxide hydrolase activity was present in all of six extrahepatic rat tissues investigated. Interestingly specific activities were very high in the heart and kidney (higher than in liver), followed by liver greater than brain greater than lung greater than testis greater than spleen. TSO and TESO hydrolases in subcellular fractions of rat liver were present at highest specific activities in the cytosolic and the heavy mitochondrial fraction. As indicated by the marker enzymes, catalase, urate oxidase and...Continue Reading

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Citations

Jan 1, 1989·Archives of Toxicology·G M PacificiF Oesch
Jan 1, 1988·Archives of Toxicology·G M PacificiF Oesch
Jul 22, 1988·Biochimica Et Biophysica Acta·J F MedinaO Rådmark
Feb 15, 1989·Biochemical Pharmacology·C L Denlinger, E S Vesell
Jan 1, 1988·Chemico-biological Interactions·J Meijer, J W DePierre
Jan 1, 1989·General Pharmacology·A F Boiteux-AntoineG Siest
Dec 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·B DienerF Oesch
Sep 1, 1988·European Journal of Biochemistry·L SchladtF Oesch
Oct 1, 1988·European Journal of Biochemistry·L SchladtF Oesch
Mar 1, 1992·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·D Utesch, F Oesch
Apr 23, 2013·Drug Metabolism Reviews·Abdulaziz M S AlsaadAyman O S El-Kadi
Mar 29, 2014·Drug Metabolism Reviews·Ursula Gundert-RemyPeter H Roos
Nov 1, 1990·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K W BockB S Bock-Hennig
Feb 1, 1997·Toxicology and Applied Pharmacology·A Viswalingam, J Caldwell
Nov 26, 2011·European Journal of Pharmacology·Nagarajan SangeethaNamasivayam Nalini
Aug 9, 2016·Cardiovascular Diabetology·Márta SárközyTamás Csont
Dec 15, 1987·Biochemical Pharmacology·P RauchL W Robertson
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Aug 13, 2015·Molecular and Cellular Biochemistry·Sivaranjani ArivalaganNalini Namasivayam
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Apr 2, 1998·Trends in Biotechnology·A Archelas, R Furstoss

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