Distribution and intraneuronal trafficking of a novel member of the chromogranin family, NESP55, in the rat peripheral nervous system

Neuroscience
J Y LiDepartment of Anatomy and Cell Biology, University of Göteborg, Sweden. jiayi.li@anatcell.gu.se

Abstract

NESP55 (neuroendocrine secretory protein of M(r) 55000) is a novel member of the chromogranin family. In the present study, we have investigated the distribution, axonal transport and proteolytic processing of NESP55 in the peripheral nervous system. The amount of NESP55 immunoreactivity in adrenal gland was more than 240 times higher than that in the vas deferens. Double or triple immunostaining demonstrated that NESP55 immunoreactivity was highly co-localized with tyrosine hydroxylase immunoreactivity in bundles of thin axons and postganglionic sympathetic neurons; that NESP55 immunoreactivity also co-existed with vesicular acetylcholine transporter immunoreactivity in large-sized axons in sciatic nerves, and that NESP55 immunoreactivity overlapped with calcitonin gene-related peptide immunoreactivity in some large-sized axons, but NESP55 immunoreactivity was not detected in sensory neurons. Strong NESP55 immunoreactivity was found in cell bodies and axons, but it was not detectable in any terminal region by immunohistochemistry. In crush-operated sciatic nerves, NESP55 immunoreactivity could be found as early as 1 h after operation, and accumulated amounts increased substantially with time. However, NESP55 immunoreactivity w...Continue Reading

References

Aug 1, 1992·Neuroscience·H Winkler, R Fischer-Colbrie
Jul 1, 1989·Journal of Microscopy·A DahlströmP A Larsson
Sep 1, 1967·British Journal of Pharmacology and Chemotherapy·F H SchneiderH Winkler
Aug 20, 1993·Brain Research. Developmental Brain Research·J Y Li, A B Dahlström
Apr 1, 1993·Neurochemistry International·L DillenW De Potter
Dec 1, 1996·The European Journal of Neuroscience·S KroesenH Winkler
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·B E HaywardD T Bonthron
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·J PetersG Kelsey
Jun 3, 1999·Brain Research·P Lovisetti-ScamihornH Winkler

❮ Previous
Next ❯

Citations

Mar 31, 2005·Molecular and Cellular Biology·Antonius PlaggeGavin Kelsey
Apr 1, 2006·Cytogenetic and Genome Research·A Plagge, G Kelsey
Dec 17, 2009·Progress in Neurobiology·Annica B Dahlstrom
Feb 3, 2005·Biological Reviews of the Cambridge Philosophical Society·Karen B Helle
Dec 11, 2007·The Journal of Comparative Neurology·Yongling LiAnnica Dahlström
Jun 10, 2008·Autonomic Neuroscience : Basic & Clinical·Yongling Li, Annica Dahlström
Aug 11, 2016·Genes, Brain, and Behavior·C L DentA R Isles
Nov 20, 2002·Annals of the New York Academy of Sciences·Reiner Fischer-ColbrieAndrea Laslop

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.