Distribution and Neurochemistry of the Porcine Ileocaecal Valve Projecting Sensory Neurons in the Dorsal Root Ganglia and the Influence of Lipopolysaccharide from Different Serotypes of Salmonella spp. on the Chemical Coding of DRG Neurons in the Cell Cultures

International Journal of Molecular Sciences
Anita MikołajczykSlawomir Gonkowski

Abstract

The ileocecal valve (ICV)-a sphincter muscle between small and large intestine-plays important roles in the physiology of the gastrointestinal (GI) tract, but many aspects connected with the innervation of the ICV remain unknown. Thus, the aim of this study was to investigate the localization and neurochemical characterization of neurons located in the dorsal root ganglia and supplying the ICV of the domestic pig. The results have shown that such neurons mainly located in the dorsal root ganglia (DRG) of thoracic and lumbar neuromers show the presence of substance P (SP), calcitonin gene-related peptide (CGRP), and galanin (GAL). The second part of the experiment consisted of a study on the influence of a low dose of lipopolysaccharide (LPS) from Salmonella serotypes Enteritidis Minnesota and Typhimurium on DRG neurons. It has been shown that the LPS of these serotypes in studied doses does not change the number of DRG neurons in the cell cultures, but influences the immunoreactivity to SP and GAL. The observed changes in neurochemical characterization depend on the bacterial serotype. The results show that DRG neurons take part in the innervation of the ICV and may change their neurochemical characterization under the impact o...Continue Reading

References

Oct 15, 1993·Biochemical and Biophysical Research Communications·C NukiA Wada
Jun 28, 2000·Journal of the Autonomic Nervous System·J B Furness
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B PulendranJ Banchereau
Nov 20, 2001·Current Opinion in Pharmacology·D WynickS B McMahon
Feb 1, 2003·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Seiji OhtoriHideshige Moriya
Jan 24, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Giovanni SarnelliJan Tack
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Minh Dang NguyenSerge Rivest
Jul 6, 2004·Autonomic Neuroscience : Basic & Clinical·Axel BrehmerWinfried Neuhuber
Apr 21, 2006·Autonomic Neuroscience : Basic & Clinical·Valentina VasinaRoberto De Giorgio
Sep 1, 2007·Stroke; a Journal of Cerebral Circulation·Marcello OrioCostantino Iadecola
Sep 13, 2007·Journal of Pediatric Surgery·Tamas CserniPrem Puri
Oct 24, 2007·Cellular and Molecular Life Sciences : CMLS·Y ShimizuJ B Furness
Jul 23, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D De FontgallandS J H Brookes
Dec 18, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Tamas CserniPrem Puri
Jan 15, 2009·Neuroscience and Behavioral Physiology·A A DorofeevaF N Makarov
May 9, 2009·PloS One·Dong-Young ChoiGuoying Bing
Dec 19, 2009·Neuroscience Letters·Maja Marinović GuićIvica Grković
May 13, 2010·The Journal of Veterinary Medical Science·Cezary SkobowiatJaroslaw Calka
Nov 23, 2010·Neuropeptides·Roland Lang, Barbara Kofler
Jan 14, 2011·Proteomics·Nisha VermaSimone Schmitz-Spanke
May 24, 2011·Parkinson's Disease·Mei Liu, Guoying Bing
Aug 26, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bernhard LoyGeorg Dechant
Nov 25, 2011·Amino Acids·Bernhard Holzmann
Jan 3, 2012·Autonomic Neuroscience : Basic & Clinical·Yasushige OhmoriNaotaka Ishiguro
Oct 2, 2012·Gut·Gianluca Matteoli, Guy E Boeckxstaens
Jul 6, 2014·Advances in Experimental Medicine and Biology·John B FurnessHyun-Jung Cho
Aug 12, 2014·Developmental Neurobiology·Letizia MarvaldiLars Klimaschewski
Nov 28, 2014·Comprehensive Physiology·Kirsteen N Browning, R Alberto Travagli
Feb 11, 2015·The Journal of Clinical Investigation·Marina AvetisyanRobert O Heuckeroth

❮ Previous
Next ❯

Software Mentioned

Statistica
Cell Sens Dimension

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.