Distribution and origin of bovine major histocompatibility complex class II DQA1 genes in Japan

Tissue Antigens
S TakeshimaY Aida

Abstract

We sequenced the major histocompatibility complex (MHC) class II DQA1 gene in 352 Japanese cattle (95 Japanese Black, 91 Holstein, 102 Japanese Shorthorn and 64 Jersey cattle) using a new sequence-based typing method. In total, 19 bovine MHC (BoLA)-DQA1 alleles, of which two were novel alleles, were detected. The Holstein, Jersey, Japanese Shorthorn and Japanese Black breeds had 13, 12, 10 and 15 alleles, respectively. The dendrogram that was constructed by the neighbor-joining method on the basis of the DQA1 gene allele frequencies of the four Japanese cattle breeds showed that the Holstein and Japanese Black breeds were closest to each other, with Jersey being farther from these two breeds than Japanese Shorthorn. In addition, Wu-Kabat analysis showed that the DQA1 alleles of the Holstein and Japanese Black were the most and least polymorphic, respectively. Phylogenetic analyses indicated that the DQA1 gene of Bovidae such as cattle, sheep, bison and goat were more similar to pig SLA-DQA genes than to human HLA-DQA1 and dog DLA-DQA genes. The cattle, goat, bison, sheep, human and pig DQA1 molecules had similar rates of amino acid sequence polymorphism, but the distribution of their polymorphic residues differed from that in t...Continue Reading

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Citations

Jan 1, 2012·ISRN Veterinary Science·Jyotsna Dhingra BehlB K Joshi
Jul 10, 2013·Biochemical Genetics·Abdulmojeed YakubuIkhide G Imumorin
Aug 21, 2010·Veterinary Immunology and Immunopathology·Saket K NiranjanSita R Sharma
May 29, 2015·Biotechnology, Biotechnological Equipment·Yongke SunYuai Yang
Jan 17, 2014·Molecular Biology Reports·Yiduo HeWeidong Deng

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