Distribution and origin of vesicular glutamate transporter 2-immunoreactive fibers in the rat hippocampus

Hippocampus
Katalin HalasyCsaba Leranth

Abstract

This study examined the distribution of vesicular glutamate transporter 2 (VGLUT2)-immunoreactive neuronal structures in the ipsilateral and contralateral hippocampi of unilateral fimbria/fornix transected, unilateral entorhinal cortex ablated, and intact female and male rats. In the hippocampi of intact animals, the highest density of VGLUT2-positive boutons was observed in the supragranular layer of the dentate gyrus, followed by the CA2 pyramidal and oriens layers, and the stratum lacunosum-moleculare of the CA1 field. This staining pattern was identical both in males and in females. Electron microscopic examination revealed that the immunolabeling was confined to axon terminals forming exclusively asymmetric synaptic contacts. The quantitative analysis of the synaptic targets of VGLUT2-positive terminals showed that in the dentate gyrus, 59% of the synaptic targets were dendritic spines, followed by dendritic shafts (22%) and granule cell somata (19%). In the pyramidal layer of the CA2 field, VGLUT2-immunoreactive boutons contacted mostly dendritic shafts (85%), only some of which (15%) synapsed with spines. The synaptic targets of VGLUT2-positive varicosities were dendritic spines (71%) and shafts (29%) in the stratum lacu...Continue Reading

References

Oct 1, 1976·The Journal of Comparative Neurology·O Steward, S A Scoville
Dec 22, 1992·The Journal of Comparative Neurology·R P Vertes
Jan 1, 1967·Zeitschrift für Zellforschung und mikroskopische Anatomie·P H Nafstad
Jan 1, 1984·Experimental Brain Research·T A Milner, D G Amaral
Sep 10, 1984·Brain Research·B B Stanfield, W M Cowan
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·B NiS M Paul
Jul 4, 2001·The Journal of Biological Chemistry·L BaiF K Ghishan
Feb 9, 2002·The Journal of Comparative Neurology·Takeshi KanekoHiroyuki Hioki
May 3, 2002·Neuroscience Research·Takeshi Kaneko, Fumino Fujiyama
Jul 13, 2002·The Journal of Comparative Neurology·Dana R ZieglerJames P Herman

❮ Previous
Next ❯

Citations

Nov 9, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hongbo HeJeffrey D Erickson
Sep 2, 2011·Trends in Neurosciences·Matthew W Jones, Thomas J McHugh
Mar 8, 2006·The European Journal of Neuroscience·Raquel Martín-IbañezTibor Harkany
Mar 21, 2006·Neurochemistry International·Jeffrey D EricksonEberhard Weihe
Apr 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jonathan MossNicolas Toni
May 21, 2016·Frontiers in Cellular Neuroscience·Christopher HeiseTobias M Boeckers
Sep 4, 2007·Progress in Brain Research·Csaba Leranth, Tibor Hajszan
Apr 11, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mari InohanaMakoto Shibutani
Dec 15, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kota NakajimaMakoto Shibutani
Jun 26, 2021·Acta Neuropathologica·Valeria RamagliaMaarten H P Kole
Jul 9, 2021·Frontiers in Neuroanatomy·Jiayan LiuNobuyoshi Matsumoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.