PMID: 8939448Oct 1, 1996Paper

Distribution and processing of peptidylglycine alpha-amidating monooxygenase activity in rat dorsal root ganglia and sciatic nerves

Neurochemistry International
H TakasugiT Kato

Abstract

Since peptidylglycine alpha-amidating monooxygenase (PAM) and carboxypeptidase H (CPH) are transported by a rapid anterograde axonal flow in rat sciatic nerves, different properties of those enzymes were examined in the cell body (dorsal root ganglia) and axon (sciatic nerves) of rat. The relative enzyme activities of soluble to membrane-associated forms in the sciatic nerves were higher than those in the ganglia. On a gel permeation chromatogram, 3 peaks (100, 70 and 30 kDa) of PAM activity appeared in both tissues. There are main peaks at 70 kDa in the ganglia and at 30 kDa in the sciatic nerves. From these data, we suppose that PAM in rat sciatic nerves is proteolytically processed during the axonal transport of secretion granules.

References

Jun 15, 1990·Biochemical and Biophysical Research Communications·K TakahashiM Noguchi
Oct 14, 1987·Biochemical and Biophysical Research Communications·H VaeröyL Terenius
Oct 15, 1986·Biochemical and Biophysical Research Communications·J SakataH Matsuo
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B A EipperC C Glembotski
May 19, 1995·Journal of Chromatography. B, Biomedical Applications·R YajimaT Kato
Oct 1, 1994·Neurochemistry International·T ChikumaA Tanaka

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