Distribution and prognostic significance of human telomerase reverse transcriptase (hTERT) expression in giant-cell tumor of bone

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Andrew E HorvaiRichard J O'Donnell

Abstract

Giant-cell tumor of bone is considered a benign, locally aggressive and rarely metastasizing neoplasm of bone. Specific microscopic or radiographic findings that reliably predict behavior have remained elusive. However, recent evidence suggests that activity of the telomerase enzyme complex correlates with recurrence in giant-cell tumor, although the subset of cells with telomerase activity in these heterogeneous tumors has not been defined. In the present study, we investigated whether immunostaining for human telomerase reverse transcriptase, a component of the telomerase complex, correlates with outcome in giant-cell tumor and the distribution of telomerase reverse transcriptase staining in these tumors. We analyzed 58 cases of giant-cell tumor for the presence and pattern of telomerase reverse transcriptase immunostaining, presence of soft tissue involvement and the type of initial surgery, and correlated these findings with recurrence-free survival and metastasis-free survival. Specific staining with telomerase reverse transcriptase was present in 20 out of 58 tumors (35%) in the nuclei of mononuclear cells and, occasionally, osteoclast-like giant cells. Furthermore, positive telomerase reverse transcriptase immunohistoche...Continue Reading

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Citations

Jul 7, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrew E HorvaiRichard J O'Donnell
Jan 6, 2016·Orthopedics·Chun-Chieh ChenHsin-Nung Shih
Mar 10, 2010·Hematological Oncology·Chiara Lobetti-BodoniMarco Ladetto
Sep 13, 2012·Experimental and Therapeutic Medicine·Mu-Han LüShi-Ming Yang
Jun 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel G BranstetterIra Jacobs

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