Nov 8, 2012

Distribution and quantification of antibiotic resistant genes and bacteria across agricultural and non-agricultural metagenomes

PloS One
Lisa M DursoBrian J Wienhold

Abstract

There is concern that antibiotic resistance can potentially be transferred from animals to humans through the food chain. The relationship between specific antibiotic resistant bacteria and the genes they carry remains to be described. Few details are known about the ecology of antibiotic resistant genes and bacteria in food production systems, or how antibiotic resistance genes in food animals compare to antibiotic resistance genes in other ecosystems. Here we report the distribution of antibiotic resistant genes in publicly available agricultural and non-agricultural metagenomic samples and identify which bacteria are likely to be carrying those genes. Antibiotic resistance, as coded for in the genes used in this study, is a process that was associated with all natural, agricultural, and human-impacted ecosystems examined, with between 0.7 to 4.4% of all classified genes in each habitat coding for resistance to antibiotic and toxic compounds (RATC). Agricultural, human, and coastal-marine metagenomes have characteristic distributions of antibiotic resistance genes, and different bacteria that carry the genes. There is a larger percentage of the total genome associated with antibiotic resistance in gastrointestinal-associated ...Continue Reading

  • References33
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Mentioned in this Paper

Vancomycin
Tetracycline Antibiotics
Antibiotic Resistance, Microbial
Tetracyclines
Alphaproteobacteria
AB-Vancomycin
Enterobacteriaceae
Aminoglycoside [EPC]
Bone Structure of Rib
Fluoroquinolones

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