Distribution and quantitation of HLA-ABC and DR (Ia) antigens on human kidney and other tissues

Transplantation
K A WilliamsP J Morris

Abstract

A quantitative estimation of the amounts of human Ia (HLA-DR) and HLA-ABC antigen on a variety of human tissues was performed. Monoclonal antibodies to species-common determinants of HLA-DR and HLA-ABC antigens were absorbed quantitatively with tissue homogenates and cell suspensions, and reassayed for residual activity in a radioimmunobinding assay. Kidney was found to carry 90% as much HLA-DR and 14% as much HLA-ABC antigen as spleen, while liver contained 19 and 9% as much, respectively. Small amounts of both antigens were found on heart; brain carried very little HLA-ABC and virtually no DR. Neither HLA-ABC nor DR was found on erythrocytes or reticulocytes. Of interest was our finding that a small subpopulation of thymocytes (10%) was HLA-DR positive. Platelets contained approximately 5% of the amount of HLA-ABC as spleen and undetectable quantities of HLA-DR, as expected. Chronic lymphatic leukemia (CLL) cells were found to carry 10% as much HLA-ABC and 33% as much DR antigen as spleen, while the values for bone marrow were 15 and 2%, respectively.

Citations

Jan 1, 1994·Annals of Neurology·D E GriffinJ M Hardwick
Dec 1, 1990·Journal of Neuroscience Research·S U Kim
Feb 1, 1991·Journal of Neuroscience Research·W F HickeyH Kimura
Jan 15, 1986·Documenta Ophthalmologica. Advances in Ophthalmology·M BakkerA Kijlstra
Dec 1, 1986·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·U K EhmannW D Peterson
Jan 1, 1995·Immunologic Research·E L OleszakC D Platsoucas
Nov 1, 1986·Veterinary Immunology and Immunopathology·J J LetessonA Depelchin
Jun 1, 1988·Journal of Neuroimmunology·E LaviS R Weiss
Dec 1, 1989·Journal of Neuroimmunology·C de Micco
Sep 1, 1990·Journal of Neuroimmunology·S Dhib-JalbutH F McFarland
Jul 1, 1991·Journal of Neuroimmunology·E P CowanS Dhib-Jalbut
Mar 1, 1993·Journal of Neuroimmunology·M B O'Malley, P R MacLeish
Jul 1, 1993·Journal of Neuroimmunology·M E SmithS Dhib-Jalbut
Jun 1, 1988·Trends in Neurosciences·V H Perry, S Gordon
Jan 1, 1990·Neuroscience·J M LawrenceG Raisman
Jun 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A R GlabinskiR M Ransohoff
Sep 29, 1999·Transplantation Proceedings·M G Crespo-LeiroA Castro-Beiras
Feb 1, 1985·Journal of Neuroimmunology·G H WongJ W Schrader
Oct 30, 2001·Virus Research·S UbolP Utaisincharoen
Oct 12, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·E VermèsD Loisance
Dec 16, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Heyman LuckrazStephen Large
Apr 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·C Alex GoddardCarla J Shatz
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A K SoodS M Weissman
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L A Lampson, C A Fisher
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R P SanetoJ de Vellis
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·W F Hickey, H Kimura
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J GogusevG F Rabotti
Jul 1, 1987·The Journal of Experimental Medicine·P T MassaV ter Meulen
Feb 1, 1988·The Journal of Experimental Medicine·H G LjunggrenK Kärre
Sep 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·P T Massa, H Wu
Nov 1, 1990·Tissue Antigens·B A RideoutN C Pedersen
Jul 1, 1981·Journal of Clinical Pathology·K A FlemingJ O McGee
Jun 1, 1997·Journal of Neuroimmunology·M Deckert-SchlüterD Schlüter
Mar 1, 1997·Journal of Neuroimmunology·T M LitchfieldR D Lund
Aug 1, 1988·Journal of Neuroimmunology·Yang Liu, A Müllbacher
Jan 13, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·R W AldridgeP D Griffiths
Nov 1, 1982·Cellular Immunology·P G NataliS Ferrone
Dec 1, 1980·Immunology Today·W M BaldwinJ J Van Rood
Aug 1, 1985·Clinical Immunology and Immunopathology·C E Alpers, J H Beckstead
May 1, 1990·Experimental Neurology·I F Pollack, R D Lund
Jul 1, 1981·Clinical Immunology and Immunopathology·P G NataliS Ferrone
Jul 1, 1989·European Journal of Immunology·A JassimH Festenstein
Jul 15, 1987·International Journal of Cancer. Journal International Du Cancer·P MöllerF Momburg
Jan 1, 1989·Journal of Neuroscience Research·S U KimD H Shin
Jan 1, 1982·Immunological Reviews·P J Morris, A Ting
Feb 1, 2017·Nature Reviews. Immunology·Thomas Korn, Axel Kallies
Jan 24, 2018·Cold Spring Harbor Perspectives in Medicine·Belinda J Kaskow, Clare Baecher-Allan
Aug 23, 1984·Nature·G H WongJ W Schrader
Jan 1, 1983·Immunological Reviews·A F GeczyJ Sullivan
Jan 1, 1984·Immunological Reviews·P HäyryR Renkonen
Dec 1, 1982·Scandinavian Journal of Immunology·E HjelmL Klareskog
Apr 7, 1999·Current Opinion in Cardiology·J A Castillo-Lugo, K R Brinker
Oct 22, 1993·The Journal of Comparative Neurology·K Rao, R D Lund
May 22, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Weikan WangDong-Ming Su
Jan 1, 1981·Tissue Antigens·P J Morris, A Ting
Apr 21, 2020·The Journal of Clinical Investigation·Christopher J HollandDavid K Cole
May 1, 1985·Current Eye Research·M Bakker, A Kijlstra
Feb 1, 1987·American Journal of Reproductive Immunology and Microbiology : AJRIM·H N HoT J Gill
Jul 1, 1980·Tissue Antigens·F M BrodskyW F Bodmer
Feb 25, 2021·The FEBS Journal·Ross A RobinsonDavid K Cole

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