Distribution and regional stressor-induced regulation of corticotrophin-releasing factor binding protein in rainbow trout (Oncorhynchus mykiss)

Journal of Neuroendocrinology
Sarah L AldermanNicholas J Bernier

Abstract

The corticotrophin-releasing factor (CRF) system plays a key role in the co-ordination of the physiological response to stress in vertebrates. Although the binding protein (BP) for CRF-related peptides, CRF-BP, is an important player in the many functions of the CRF system, the distribution of CRF-BP and the impact of stressors on its expression in fish are poorly understood. In the present study, we describe the distribution of CRF-BP in the brain and peripheral tissues of rainbow trout (Oncorhynchus mykiss) using a combination of real-time reverse transcriptase-polymerase chain reaction, in situ hybridisation and immunohistochemistry. Our results indicate a widespread and highly localised distribution of CRF-BP in the central nervous system, but do not support a significant peripheral production of the protein. Major expression sites in the brain include the area ventralis telencephali, nucleus preopticus, anterior and lateral tuberal nuclei, and the posterior region of the pituitary pars distalis. We further characterise changes in CRF-BP gene expression in three discrete brain regions after exposure to 8 h and 24 h of social stress or hypoxia. The plasma cortisol concentration in subordinate fish was much higher than in dom...Continue Reading

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Citations

Nov 26, 2013·General and Comparative Endocrinology·J D JeffreyK M Gilmour
Feb 14, 2012·General and Comparative Endocrinology·Jennifer D JeffreyKathleen M Gilmour
Jan 12, 2012·General and Comparative Endocrinology·Sarah L AldermanMathilakath M Vijayan
May 27, 2008·General and Comparative Endocrinology·Chun-Chun Chen, Russell D Fernald
May 22, 2009·Annals of the New York Academy of Sciences·Robert John Denver
Aug 5, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Juan A Martos-SitchaGonzalo Martínez-Rodríguez
Apr 17, 2014·General and Comparative Endocrinology·Manuel GestoMarta Conde-Sieira
Apr 25, 2017·Stress : the International Journal on the Biology of Stress·Kyle D KetchesinAudrey F Seasholtz
Nov 23, 2017·Frontiers in Neuroscience·Yuki HiguchiIshwar S Parhar
Nov 9, 2018·Frontiers in Endocrinology·Marta Conde-SieiraJosé L Soengas
May 29, 2018·General and Comparative Endocrinology·Sarah L AldermanNicholas J Bernier
Jun 10, 2015·The Journal of Experimental Biology·Angelico MadaroMarnix Gorissen

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