Distribution and regulation of protein expression of the free fatty acid receptor GPR120.

Naunyn-Schmiedeberg's Archives of Pharmacology
Satoshi MiyauchiGozoh Tsujimoto

Abstract

GPR120 is a G-protein-coupled receptor whose endogenous ligands have recently been identified as free fatty acids. It has been implicated as playing an important role in the control of lipid and glucose metabolism by regulating the secretion of glucagon-like peptide-1 and cholecystokinin. We have developed an antibody against the extracellular domain of GPR120. The specificity of the antibody was demonstrated by immunoprecipitation, Western blotting, flow cytometry, and immunocytochemistry using GPR120-transfected cells. Immunoreactivity for GPR120 was abundant in the mouse large intestine, lung, and adipose tissue. Furthermore, we found that the expression of GPR120 protein was up-regulated during the adipogenic differentiation of 3T3-L1 cells, which corresponded well with changes in mRNA expression. The anti-GPR120 antibody will be of value for the further study of the function of this nutrient-sensing receptor.

References

May 20, 1996·FEBS Letters·A HirasawaG Tsujimoto
Jun 26, 1999·The Journal of Biological Chemistry·F Y Zeng, J Wess
Feb 24, 2001·Annals of the New York Academy of Sciences·G Singh, S L Katyal
Dec 24, 2002·The Journal of Biological Chemistry·Celia P BriscoeAlison I Muir
Dec 28, 2004·Nature Medicine·Akira HirasawaGozoh Tsujimoto
Mar 19, 2005·The Journal of Biological Chemistry·Susumu KatsumaGozoh Tsujimoto
Aug 27, 2005·Endocrinology·Yeon-Hee HongShinichi Sasaki
Jan 26, 2007·Biochemical and Biophysical Research Communications·Chizu GotohSang-Gun Roh
Nov 1, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Toshiki TanakaGozoh Tsujimoto
Nov 6, 2007·Biochemical and Biophysical Research Communications·Akira HirasawaGozoh Tsujimoto

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Citations

Jan 28, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Martin C MichelGozoh Tsujimoto
May 28, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Takafumi HaraGozoh Tsujimoto
Nov 11, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Silke BeermannDetlef Neumann
Jul 31, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Mark N AdamsJohn D Hooper
Dec 2, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Akira HirasawaGozoh Tsujimoto
Dec 4, 2012·Marine Drugs·Fraser D Russell, Corinna S Bürgin-Maunder
Apr 21, 2012·Advances in Nutrition·Anastasia Georgiadi, Sander Kersten
Oct 29, 2013·Annual Review of Pharmacology and Toxicology·Stefan Offermanns
Nov 10, 2013·Pharmacology & Therapeutics·Clara M YatesG Ed Rainger
Aug 15, 2009·Expert Opinion on Investigational Drugs·Kjetil Retterstøl
May 28, 2011·Journal of Pharmaceutical Sciences·Takafumi HaraGozoh Tsujimoto
May 1, 2012·Progress in Lipid Research·Dong-Soon Im
Sep 3, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Kristina MooreRuth Duffy
May 23, 2009·Prostaglandins & Other Lipid Mediators·Atsuhiko IchimuraGozoh Tsujimoto
Jun 2, 2015·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Akira Hirasawa
Nov 19, 2015·Journal of Molecular Endocrinology·Kun ChenYuanzhu Xiong
Feb 20, 2016·Metabolism: Clinical and Experimental·Rosmarie ClaraAbdelhak Mansouri
Mar 22, 2012·British Journal of Pharmacology·Amanda J PageRichard L Young
Oct 1, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M C P GeraedtsW H M Saris
Aug 8, 2009·Biochemical Pharmacology·Noel G Morgan, Shalinee Dhayal
Sep 1, 2015·Neurochemistry International·Kusumika GharamiSumantra Das
Jul 1, 2015·European Journal of Pharmacology·Hong-Da LiuJin-peng Sun
Dec 10, 2013·Drug Discovery Today·Lauren M CornallAndrew J McAinch
Jul 18, 2015·Annual Review of Nutrition·Trond Ulven, Elisabeth Christiansen
Jun 16, 2015·BioMed Research International·Tongxing SongJian Peng
Jun 14, 2014·Biochimica Et Biophysica Acta·Takafumi HaraAkira Hirasawa
Aug 1, 2014·Frontiers in Endocrinology·Da Young Oh, Evelyn Walenta
Jul 30, 2014·Frontiers in Endocrinology·Atsuhiko IchimuraAkira Hirasawa
Aug 13, 2014·Histochemistry and Cell Biology·Ryutaro MoriyamaNobuyuki Fukushima
Jan 23, 2010·Journal of Pharmacological Sciences·Satoshi MiyauchiGozoh Tsujimoto
Jun 15, 2016·Chemical Reviews·Graeme MilliganBrian D Hudson
Jan 25, 2018·Journal of Cellular Biochemistry·Cecilia Rodriguez-MonterrosasEduardo P Salazar
Jun 7, 2017·Journal of Lipid Research·Santhosh SatapatiJin Shang

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