Distribution and resistance of pathogens in infected patients within 1 year after heart transplantation.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Yaya ZhouJianchu Zhang

Abstract

Infection is a major cause of morbidity and mortality after heart transplantation (HT). However, there have been few data on clinical manifestation, distribution, and resistance of pathogens in the infected population of heart transplant recipients. We conducted a single-center retrospective study on patients who underwent HT in Wuhan Union Hospital from August 3, 2012 to July 30, 2016. Risk factors for infections that occur within 1 year after HT were investigated by multivariable logistic regression analysis. Among 299 patients, 147 patients (49.2%) confirmed infection. The most common site of infection was the respiratory system. A total of 259 pathogens were detected in 147 patients (49.2%) with infection after HT. In all, 64 multidrug-resistant (MDR) bacteria were detected in infected patients within 1 year after HT, the most common MDR bacteria were extended-spectrum β-lactamases (ESBL) Klebsiella pneumonia and methicillin-resistant Staphylococcus aureus (MRSA). In the multivariable model, diabetes (OR 3.273 [95%CI, 1.748-6.130], and p < .001) and antibiotics treatment within 1 month before transplant (OR 1.860 [95%CI, 1.093-3.166], and p = .022) were significantly associated with infections within 1 year after HT. This s...Continue Reading

References

Aug 26, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J M CisnerosA Echaniz
Aug 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J G MontoyaJ S Remington
Aug 15, 2001·Chest·R LennerG J Schilero
Jan 24, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A HumarUNKNOWN AST ID Working Group on Infectious Disease Monitoring
Mar 10, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Frauke MattnerMartin Strueber
Dec 21, 2007·The New England Journal of Medicine·Jay A Fishman
Mar 5, 2008·Mayo Clinic Proceedings·Diederik van de BeekRobin Patel
Apr 30, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jean C RousselPhilippe Despins
Mar 28, 2009·The Lancet Infectious Diseases·Patrice NordmannThierry Naas
Mar 23, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Shahid HusainUNKNOWN ISHLT Infectious Diseases Council Working Group on Definitions
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D van DuinUNKNOWN AST Infectious Diseases Community of Practice
Apr 26, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshiya ToyodaAbul Kashem
Sep 24, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lars H LundUNKNOWN International Society for Heart and Lung Transplantation
May 28, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C CerveraUNKNOWN ESCMID Study Group for Infections in Compromised Hosts
Apr 4, 2015·PloS One·Simone LaniniUNKNOWN Donor-Recipient Infection (DRIn) Collaborative Study Group
Jan 19, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mandeep R MehraUNKNOWN International Society for Heart Lung Transplantation (ISHLT) Heart Failure and Transplantation Council
Nov 19, 2018·Critical Care Clinics·Mohammed Alsaeed, Shahid Husain
May 12, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Paula Fernández-UgidosMaría G Crespo-Leiro
Oct 5, 2019·Surgical Infections·Rocío Gómez-LópezMaría G Crespo-Leiro
Nov 26, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Pinki J BhattSarah Taimur

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatrics International : Official Journal of the Japan Pediatric Society
Burcu BulumFatoş Yalçınkaya
Climacteric : the Journal of the International Menopause Society
A Strothmann, H P G Schneider
Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
Hélder DoresFátima Ceia
© 2021 Meta ULC. All rights reserved