Distribution and risk of the second discordant primary cancers combined after a specific first primary cancer in German and Swedish cancer registries

Cancer Letters
Tianhui ChenGEKID Cancer Survival Working Group

Abstract

We aimed at investigating the distribution and risk of all second discordant primary cancers (SDPCs) after a specific first primary cancer in Germany and Sweden to provide etiological understanding of SDPCs and insight into their incidence rates and recording practices. Among 1,537,004 survivors of first primary cancers in Germany and 588,103 in Sweden, overall 80,162 and 32,544 SDPCs were recorded, respectively. Standardized incidence ratios (SIRs) of all SDPCs were elevated at levels between 1.1 and 2.1 after 23 (out of overall 29) cancers in Germany and at levels between 1.1 and 1.6 after 24 cancers in Sweden, and among them, elevated SIRs were found after 19 cancers in both populations. Decreased SIRs at levels ranging from 0.5 to 0.9 were found for some cancers with poor prognosis in Germany only. We found elevated risk after 19 out of 29 cancers in both countries, suggesting common etiology of SDPCs after most of first cancers and registration similarity. Decreased risks after some fatal cancers were found only in Germany, which may be attributed to reporting practices or missed death data in Germany.

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Citations

Dec 23, 2016·International Journal of Cancer. Journal International Du Cancer·Christoph FrankKari Hemminki
Oct 3, 2018·Cancer Medicine·Subhayan ChattopadhyayKari Hemminki
Aug 18, 2017·International Journal of Cancer. Journal International Du Cancer·Tianhui ChenUNKNOWN GEKID Cancer Survival Working Group+
Sep 7, 2018·Prostate Cancer and Prostatic Diseases·Subhayan ChattopadhyayKari Hemminki
Aug 7, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Crystal S DenlingerDeborah A Freedman-Cass
Nov 28, 2018·Cancer Medicine·Guoqiao ZhengKari Hemminki
Jul 31, 2019·JNCI Cancer Spectrum·Subhayan ChattopadhyayKari Hemminki
Nov 15, 2017·International Journal of Cancer. Journal International Du Cancer·Tianhui ChenUNKNOWN GEKID Cancer Survival Working Group
Aug 3, 2021·European Urology Open Science·Guoqiao ZhengKari Hemminki

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