Distribution and roles of X-family DNA polymerases in eukaryotes

Biochimie
Yukinobu UchiyamaKengo Sakaguchi

Abstract

Four types of DNA polymerase (Pol beta, Pol lambda, Pol mu and TdT) have been identified in eukaryotes as members of the polymerase X-family. Only vertebrates have all four types of enzyme. Plants and fungi have one or two X-family polymerases, while protostomes, such as fruit flies and nematodes, do not appear to have any. It is possible that the well-known metabolic pathways in which these enzymes are involved are restricted to the vertebrate world. The distribution of the DNA polymerases involved in DNA repair across the various biological kingdoms differs from that of the DNA polymerases involved in chromosomal DNA replication. In this review, we focus on the interesting pattern of distribution of the X-family enzymes across biological kingdoms and speculate on their roles.

References

Oct 2, 2001·The Journal of Biological Chemistry·P M BurgersR Woodgate
Jul 8, 2003·Science of Aging Knowledge Environment : SAGE KE·Polina V ShcherbakovaThomas A Kunkel
May 14, 2004·Nucleic Acids Research·Irina I DianovaGrigory L Dianov
Jun 23, 2004·European Journal of Biochemistry·Yukinobu UchiyamaKengo Sakaguchi
Mar 22, 2005·The Journal of Biological Chemistry·Katarzyna BebenekThomas A Kunkel
Aug 29, 2006·Neuroscience·D M Wilson, D R McNeill
May 25, 2007·Plant Molecular Biology·Ryo TakeuchiKengo Sakaguchi
Apr 9, 2008·Biochemistry. Biokhimii︠a︡·A V MakarovaL V Gening

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Citations

Apr 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Alireza G SenejaniJoann B Sweasy
Jul 24, 2010·Antioxidants & Redox Signaling·Dale A Ramsden
Jul 17, 2012·Antioxidants & Redox Signaling·Jason L ParsonsRicky A Sharma
Aug 20, 2010·RNA·Adonis SkandalisMiriam H Richards
Jun 14, 2014·PloS One·Jenni LiljavirtaAntti Iivanainen
Oct 27, 2010·Journal of Nucleic Acids·Danielle Gomes Passos-SilvaCarolina Furtado
May 9, 2012·Drug Discovery Today·Khaled H BarakatJack A Tuszynski
Oct 29, 2011·Biochemical and Biophysical Research Communications·Hirofumi KoderaKengo Sakaguchi
Jan 5, 2011·Journal of Molecular Graphics & Modelling·Khaled Barakat, Jack Tuszynski
Jul 28, 2009·Biochimica Et Biophysica Acta·Jennifer Yamtich, Joann B Sweasy
Jul 15, 2009·Biochimica Et Biophysica Acta·Edward A Motea, Anthony J Berdis
Jul 26, 2011·The Plant Journal : for Cell and Molecular Biology·Dolores Córdoba-CañeroRafael R Ariza
Sep 19, 2012·Environmental and Molecular Mutagenesis·Dale A Ramsden, Kenjiro Asagoshi
Aug 13, 2014·DNA Repair·Rachelle J BienstockSamuel H Wilson
Nov 18, 2010·Biophysical Journal·Yunlang Li, Tamar Schlick
Apr 11, 2014·Biochemistry·Katarzyna BebenekThomas A Kunkel
Jun 23, 2018·Traffic·Thomas W KirbyRobert E London
Mar 2, 2018·Annual Review of Biochemistry·Wei Yang, Yang Gao
Aug 18, 2009·The Plant Journal : for Cell and Molecular Biology·Dolores Córdoba-CañeroRafael R Ariza
Nov 14, 2019·Cellular and Molecular Life Sciences : CMLS·Nicole M HoitsmaBret D Freudenthal
Nov 12, 2015·Frontiers in Plant Science·Vasilissa Manova, Damian Gruszka
Nov 30, 2018·BMC Evolutionary Biology·Bette J Hecox-Lea, David B Mark Welch
Apr 1, 2021·The FEBS Journal·Dipayan Ghosh, Sathees C Raghavan
Feb 9, 2021·Annual Review of Biochemistry·Benjamin M Stinson, Joseph J Loparo
Aug 26, 2017·Chemical Research in Toxicology·Barbara van LoonGiovanni Maga

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