PMID: 11932938Apr 5, 2002Paper

Distribution and synaptic connectivity of neuropeptide Y-immunoreactive amacrine cells in the rat retina

The Journal of Comparative Neurology
Su-Ja OhN C Brecha

Abstract

Neuropeptide Y (NPY) is a potent bioactive peptide that is widely expressed in the nervous system, including the retina. Here we show that specific NPY immunoreactivity was localized to amacrine and displaced amacrine cells in the rat retina. Immunoreactive cells had a regular distribution across the retina and an overall cell density of 280 cells/mm(2) in the inner nuclear layer (INL) and 90 cells/mm(2) in the ganglion cell layer (GCL). In the INL, most immunoreactive cells were characterized by small cell bodies and fine processes that appeared to ramify primarily in stratum 1 of the inner plexiform layer (IPL). A few cells in the INL also ramified in stratum 3 of the IPL. In the GCL, small to medium immunoreactive cells appeared to ramify primarily in stratum 5 of the IPL. A few immunoreactive processes, originating from somata in the INL and processes in the IPL, ramified in the OPL. NPY-immunoreactive cells contained GABA immunoreactivity, and some amacrine cells also contained tyrosine hydroxylase immunoreactivity. NPY-immunostained processes were most frequently presynaptic to nonimmunostained amacrine and ganglion cell processes and postsynaptic to nonimmunostained amacrine cell processes and cone bipolar cell axonal te...Continue Reading

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Citations

Nov 13, 2002·Clinical & Experimental Ophthalmology·Helen Z YoonRosemary D Higgins
Aug 30, 2014·Current Ophthalmology Reports·Revathi Balasubramanian, Lin Gan
Mar 14, 2007·Neurochemistry International·Ana Rita AlvaroCláudia Cavadas
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Apr 18, 2018·The Journal of Comparative Neurology·Anders Tolstrup ChristiansenJens Hannibal
Sep 11, 2003·The Journal of Comparative Neurology·Tatjana C JakobsRichard H Masland
Jun 14, 2005·The Journal of Comparative Neurology·Tae-Hoon KangMyung-Hoon Chun
Nov 9, 2018·Frontiers in Physiology·Qian ZhangXiaojing Wang

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