Distribution and types of adrenoceptors in the guinea-pig ileum: the action of alpha- and beta-adrenoceptor agonists

British Journal of Pharmacology
V Bauer

Abstract

1 Segments of guinea-pig ileum and the myenteric plexus-longitudinal smooth muscle preparation were used for a study of the actions of adrenaline, noradrenaline, isoprenaline, ephedrine and phenylephrine on the responses of coaxially stimulated ileum at different distances from the ileocaecal valve.2 The responses of the ileum to electrical stimulation were suppressed by adrenaline, nonadrenaline and ephedrine, while phenylephrine and isoprenaline inhibited them only partially.3 The twitch inhibition elicited by these adrenoceptor agonists was the same at all distances from the ileocaecal valve. There was no significant difference between their cumulative and non-cumulative concentration-response curves.4 Smooth muscle relaxation was induced only by isoprenaline and contraction only by phenylephrine at all distances from the ileocaecal junction. Adrenaline and noradrenaline evoked smooth muscle contraction in the terminal (0 to 20 cm), a concentration-dependent, biphasic response in the intermediate part (21 to 50 cm) and a relaxation in the proximal ileum (> 50 cm from the ilecocaecal valve). Ephedrine did not change significantly the smooth muscle tension in the terminal and the intermediate segments and induced smooth muscle...Continue Reading

References

Jan 1, 1979·Journal of Pharmaceutical Sciences·M F TansyF M Kendall
Mar 1, 1976·British Journal of Pharmacology·A A Anderson, G M Lees
Jul 1, 1971·The Journal of Physiology·W D PatonM A Zar
Mar 11, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E Bülbring, T Tomita
Mar 11, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E Bülbring, T Tomita
Feb 1, 1970·British Journal of Pharmacology·W C Bowman, M T Hall
Sep 1, 1971·The Journal of Physiology·R CasteelsH Hendrickx
Jan 1, 1971·Zeitschrift für Zellforschung und mikroskopische Anatomie·M Costa, G Gabella
Feb 10, 1967·Annals of the New York Academy of Sciences·T M Brody, J Diamond
Mar 1, 1969·British Journal of Pharmacology·I R Innes, J D Kohli
Jun 1, 1954·British Journal of Pharmacology and Chemotherapy·M D McDOUGAL, G B WEST
Sep 1, 1964·International Journal of Neuropharmacology·K A NORBERG

❮ Previous
Next ❯

Citations

Sep 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·R E Loiacono, D F Story
Dec 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·K J Broadley, P F Grassby
May 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·V BauerH Kuriyama
Dec 17, 1985·European Journal of Pharmacology·M L Vargas, A J Brugger
Jan 1, 1982·Toxicon : Official Journal of the International Society on Toxinology·A M Cameron, R J Lewis
Jan 1, 1990·General Pharmacology·E AtanassovaA Noeva
Mar 25, 2014·Journal of Natural Medicines·Yongjian XiongYuan Lin
Jan 29, 2014·Fitoterapia·Yong-Jian XiongYuan Lin
Feb 1, 1984·British Journal of Pharmacology·J FontaineJ Reuse

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.