Distribution change of mast cells in human nasal polyps

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Guimin ZhangJie Yang

Abstract

Recent studies have shown that mast cells are involved in pathophysiologic processes of chronic inflammation. However, little is known about the distribution of mast cells in nasal polyps, which is a chronic inflammatory disease of the upper airways. Biopsy specimens from patients with nasal polyps (n = 20) and control patients without nasal polyps (n = 8) were included in this study. The distribution of mast cells in nasal polyps was determined by immunohistochemistry. Meanwhile, we detected the expression of chemokines (CCL5, CCL11, CX3CL1, IL-8, IL-6) in the epithelial cells of normal nasal mucosa and nasal polyps. In addition, the expression of these chemokines was investigated by western bolting in airway epithelial cells line (A549 cells) under inflammatory condition. Mast cells migrated toward intraepithelium in nasal polyps and the expression of chemokines (CCL5, CCL11, CX3CL1, IL-8) was up-regulated in the epithelial cells of nasal polyps compared with normal nasal mucosa. The expression of chemokines was also up-regulated in A549 cells after Lipopolysaccharide (LPS)-treatment for 3 hr and 6 hr. Our findings showed that mast cells migrate toward intraepithelium in nasal polyps and the overexpression of chemokines (CCL5...Continue Reading

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Citations

Aug 13, 2013·Fertility and Sterility·Tania El-HamarnehKirsten Black
Aug 6, 2015·Allergologia et immunopathologia·R KhalmuratovaH-W Shin
Mar 5, 2013·The Journal of Allergy and Clinical Immunology·Koji SugawaraRalf Paus
Aug 6, 2013·Otolaryngologia polska. The Polish otolaryngology·Sylwia ChojnowskaSławomir Dariusz Szajda
Feb 2, 2018·Immunological Investigations·Guimin ZhangPeng Lin
Jan 29, 2020·Expert Review of Clinical Immunology·Chengshuo WangLuo Zhang
May 20, 2020·Cell Adhesion & Migration·Joanna PastwińskaJarosław Dastych

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