PMID: 590227Dec 1, 1977

Distribution characteristics of ethosuximide in discrete areas of rat brain

I H PatelR L Rapport


The distribution properties of ethosuximide in four regions of the rat brain--cortex, midbrain, cerebellum, and pons-medulla--were investigated following chronic intraperitoneal administration of the drug (every 12 hr for 108 hr) at four dose levels (20, 40, 60, and 80 mg/kg). A gas-liquid chromatographic procedure was developed to quantitate ethosuximide levels in these tissues and plasma. The mean tissue/plasma ratios were 0.917, 0.942, 0.902, and 0.903 for cortex, midbrain, cerebellum, and pons-medulla, respectively. The distribution ratio for midbrain was significantly greater than that observed for cerebellum. For each brain region, the distribution ratio was independent of dose (20 to 80 mg/kg) and plasma concentration (8 to 135 microgram/ml).


Jan 1, 1975·Journal of Pharmaceutical Sciences·M A GonzalezT T Chang
Oct 10, 1975·European Journal of Clinical Pharmacology·G W Houghton Falconer
Aug 1, 1971·Biochemical Pharmacology·P L MorselliS Garattini
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Dec 18, 2001·Biopharmaceutics & Drug Disposition·J MifsudJ S Millership
Dec 18, 2001·Biopharmaceutics & Drug Disposition·J MifsudW C McRoberts
Jul 14, 2007·CNS Drug Reviews·M Zafer Gören, Filiz Onat
Mar 1, 1989·Biomedical Chromatography : BMC·J Galán-ValienteG Sierra-Marcuño
Sep 16, 2014·Pflügers Archiv : European journal of physiology·Chiung-Wei Huang, Chung-Chin Kuo

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