Distribution density of intraepidermal nerve fibers in normal human skin

The Journal of Dermatology
T KawakamiM Mihara

Abstract

A total of 74 specimens was obtained from the normal human skin of patients from 3 to 90 years old. The specimens were roughly classified into 5 groups: 15 for the face group from the face; 15 for the abdomen group from the abdomen; 13 for the back group from the back; 14 for the arm group from the upper arm and forearm; and 17 for the leg group from the thigh and lower leg. They were all fixed in 4% paraformaldehyde and 14% saturated picric acid. Cryostat sections were examined by the immunoperoxidase method and indirect immunofluorescence (IF). Primary antibodies against neurofilament, neuron-specific enolase, protein gene product 9.5 (PGP 9.5) and S-100 protein were used. The most effective method was found to be the combination of IF with PGP 9.5; it visualized the intraepidermal nerve fibers easily and clearly. Of the 74 specimens, 32 (43%) had intraepidermal PGP 9.5-immunoreactive (or nerve) fibers (IPIF), and 42 (57%) did not have any. With reference to the different skin locations, the maximal rate of specimens having IPIF was 57% in the arm group, and the minimum was 23% in the back group. IPIF positive specimens had approximate surface lengths of 6 mm, in which the existence number of the IPIF was 1 to 75. Their distr...Continue Reading

References

Jul 1, 1977·The Journal of Investigative Dermatology·A S Breathnach
Oct 1, 1992·The Journal of Allergy and Clinical Immunology·D TobinH J Schuurman
Jul 1, 1990·Cell and Tissue Research·L WangO Johansson
Oct 1, 1988·Cell and Tissue Research·G E Novotny, E Gommert-Novotny
Aug 1, 1994·The British Journal of Dermatology·M S Al'AbadieD J Gawkrodger
Apr 1, 1993·Journal of the Neurological Sciences·W R Kennedy, G Wendelschafer-Crabb
May 16, 1998·Virchows Archiv : an International Journal of Pathology·R Urashima, M Mihara
Sep 10, 1998·International Journal of Dermatology·W Y JiangE M Farber
Aug 10, 2000·Archives of Dermatological Research·E HagforsenG Michaëlsson
Mar 1, 1959·The Journal of Investigative Dermatology·R P ARTHUR, W B SHELLEY

❮ Previous
Next ❯

Citations

Dec 7, 2002·Regulatory Peptides·Sonja StänderMartin Steinhoff
Jul 18, 2008·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Cheng-Jen ChangJ Stuart Nelson
Aug 4, 2012·Clinical Physiology and Functional Imaging·Kristen Metzler-WilsonThad E Wilson
Oct 4, 2005·Burns : Journal of the International Society for Burn Injuries·Bernadette NedelecRobert W Dykes
Apr 17, 2015·BMC Geriatrics·Janine van KootenErik J A Scherder
Oct 16, 2015·Research in Developmental Disabilities·Nanda de KnegtErik Scherder
Sep 30, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G LauriaUNKNOWN European Federation of Neurological Societies
Oct 21, 2017·Journal of Oral Rehabilitation·L K DagsdóttirP Svensson
Feb 3, 2011·Plastic and Reconstructive Surgery·Maria SiemionowAntonio Rampazzo
Jan 14, 2015·Translational Neuroscience·Huan WangBrad Sutton
Sep 6, 2013·The Journal of the American Osteopathic Association·Karen T SniderJane C Johnson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.