Distribution, genetic diversity, and variable expression of the gene encoding hyaluronate lyase within the Streptococcus suis population

Journal of Bacteriology
S J KingA M Whatmore

Abstract

Although Streptococcus suis is an economically important pathogen of pigs and an occasional cause of zoonotic infections of humans knowledge of crucial virulence factors, and as a consequence targets for therapeutic or prophylactic intervention, remains limited. Here we describe a detailed study of the distribution, diversity, and in vitro expression of hyaluronate lyase, a protein implicated as a virulence factor of many mucosal pathogens. The gene encoding hyaluronate lyase, hyl, was present in all 309 bona fide S. suis isolates examined representing diverse serotypes, geographic sources, and clinical backgrounds. Examination of the genetic diversity of hyl by RFLP and sequence analysis indicated a pattern of diversity shared by many gram-positive surface proteins with a variable 5' region encoding the most distal cell surface-exposed regions of the protein and a much more conserved 3' region encoding domains more closely associated with the bacterial cell. Variation occurs by several mechanisms, including the accumulation of point mutations and deletion and insertion events, and there is clear evidence that genetic recombination has contributed to molecular variation in this gene. Despite the ubiquitous presence of hyl, the ...Continue Reading

References

Nov 1, 1991·Journal of Clinical Microbiology·M GottschalkJ Henrichsen
Jan 1, 1991·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·M GottschalkJ Henrichsen
Dec 1, 1989·Journal of Clinical Microbiology·M GottschalkJ Henrichsen
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J M MusserR K Selander
May 1, 1989·Journal of Clinical Pathology·P F Unsworth
Jan 1, 1988·Reviews of Infectious Diseases·J P Arends, H C Zanen
Jun 1, 1983·Journal of Clinical Microbiology·B PerchJ Henrichsen
Jul 1, 1995·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·R HigginsJ Henrichsen
Nov 1, 1994·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·C PrietoJ M Castro
Oct 1, 1994·Epidemiology and Infection·C G MwanikiD J Hampson
May 1, 1994·The British Veterinary Journal·P L TurgeonM Beaudoin
Aug 1, 1993·Infection and Immunity·D G Pritchard, B Lin
Jan 1, 1996·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·R Y ReamsT L Bowersock
Aug 1, 1997·Veterinary Research Communications·J J StaatsM M Chengappa
Jul 24, 1998·Journal of Clinical Microbiology·B FrançoisP Vignon
Sep 10, 1998·International Journal of Systematic Bacteriology·S ChatellierR Brousseau
Nov 24, 1998·Infection and Immunity·A PolissiD Simon
May 13, 1999·Journal of Bacteriology·A M WhatmoreC G Dowson
Feb 17, 2000·FEMS Microbiology Letters·W L Hynes, S L Walton
Sep 6, 2000·Veterinary Microbiology·M Gottschalk, M Segura
Mar 10, 2001·The Journal of Infectious Diseases·P J ZwijnenburgA M van Furth
Mar 27, 2001·The Veterinary Record·P J Heath, B W Hunt
Jul 18, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·A A HassanR Huber-Schlenstedt

❮ Previous
Next ❯

Citations

Aug 9, 2012·Clinical Medicine Insights. Cardiology·Orathai PachiratAnusak Kerdsin
Apr 19, 2011·Nihon saikingaku zasshi. Japanese journal of bacteriology·Daisuke Takamatsu
Nov 26, 2010·Microbial Pathogenesis·Tao WuHuanchun Chen
Oct 1, 2015·BMC Infectious Diseases·Rujirat HatrongjitYukihiro Akeda
Mar 4, 2008·Microbiology·D PecharkiA Aa Scheie
Jul 1, 2016·Future Microbiology·Tobias TenenbaumChristian Schwerk
Jun 30, 2009·Animal Health Research Reviews·Christoph Georg Baums, Peter Valentin-Weigand
Mar 5, 2014·Transboundary and Emerging Diseases·K ManeeratP Srimanote

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.