Distribution of 125I-labeled rat growth hormone in regional brain areas and peripheral tissue of the rat

The American Journal of Anatomy
W C SternP J Morgane

Abstract

The uptake of intraperitoneally injected 125I-labeled rat growth hormone into brain and peripheral tissues was measured in normal and hypophysectomized adult rats. A significant level of radioactivity was observed in the seven brain regions examined -- the telencephalon, diencephalon, midbrain, pons-medulla, cerebellum, pineal and pituitary glands. The pineal and pituitary glands, which are outside the blood-brain barrier, contained three to four times the concentration of radioactivity of the other brain regions. Compared to brain, the level of radioactivity was much higher in peripheral tissues (the diaphragm, kidney, serum and liver). For example, the serum contained ten times the level of radioactivity of most brain regions. For a given tissue, however, the normal and hypophysectomized rats showed a comparable amount of 125I-growth hormone. Trichloroacetic acid precipitates from each tissue sample showed that peripheral tissues had a higher proportion of radioactivity (35-48% of total tissue radioactivity) than the brain samples (13-26%). The data support the view that growth hormone, or a metabolite can enter the central nervous system and may directly affect on-going metabolic processes.

References

Jan 1, 1975·Neuroendocrinology·R R Drucker-ColínJ L McGaugh
Jun 1, 1975·Hormones and Behavior·W C SternP J Morgane
Nov 1, 1973·The Journal of Clinical Investigation·J B MillsA E Wilhelmi
Nov 1, 1974·Endocrinology·G A Hagen, L A Solberg
Nov 1, 1974·Science·V R SaraT King
May 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J L Kostyo, D F Nutting
Aug 1, 1970·The Journal of Clinical Endocrinology and Metabolism·J A LinfootJ H Lawrence
Oct 1, 1963·The Biochemical Journal·F C GREENWOODJ S GLOVER

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Citations

Jun 1, 1983·Hormones and Behavior·P H Kelly
Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P E LobieE L Goh
Jul 7, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·M Coculescu

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