PMID: 2120398Oct 1, 1990Paper

Distribution of [14C]canthaxanthin and [14C]lycopene in rats and monkeys

The Journal of Nutrition
M M Mathews-RothN I Krinsky

Abstract

The absorption and distribution of [14C]-canthaxanthin and [14C]lycopene were studied in rats and in rhesus monkeys following the oral administration of [14C]canthaxanthin or [14C]lycopene in olive oil supplemented with 1 mg alpha-tocopherol/mL. For canthaxanthin and lycopene, peak accumulation of radioactivity in plasma occurred between 4 and 8 h in rats and between 8 and 48 h in monkeys. In rats, the liver contained the largest amount of both kinds of radioactive pigments. In monkeys, with the exception of one stomach sample, liver was also the major depot organ for both canthaxanthin and lycopene. The other organs tested accumulated various amounts of pigment. No labeled metabolic products of either canthaxanthin or lycopene were found.

Citations

Nov 26, 1999·The Journal of Nutrition·C M LeeJ W Erdman
Nov 9, 2002·Experimental Biology and Medicine·Thomas W-M BoileauJohn W Erdman
Jun 25, 2009·International Journal of Cancer. Journal International Du Cancer·Yan WangXiang-Dong Wang
Sep 1, 1996·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S GradeletP O Astorg
May 10, 2000·The Journal of Nutrition·A L FerreiraR M Russell
Sep 2, 2003·The Journal of Nutrition·Peter J KorytkoBarry S Levine
Oct 19, 2010·Veterinary Medicine International·Ibrahim Halil BahceciogluOmer Kucuk
Feb 20, 1999·The Journal of Nutrition·K A SlifkaS D Crissey
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Jan 18, 2017·Nutrition and Cancer·Hatice CoskunOmer Kucuk
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Aug 28, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wageh S DarwishMayumi Ishizuka

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