Distribution of 2,4-dichlorophenoxyacetic acid (2,4-D) in maternal and fetal rabbits

Journal of Toxicology and Environmental Health
J A SandbergC S Kim

Abstract

The distribution of 2,4-dichlorophenoxyacetic acid (2,4-D) was examined in maternal and fetal rabbits. Pregnant New Zealand rabbits (28-30 d gestational age) were anesthetized with ketamine/xylazine and the femoral vein and artery were catheterized for compound administration and sampling. Dams received iv [14C]2,4-D (12.5 microCi/kg) with unlabeled sodium 2,4-D (1, 10, or 40 mg/kg) in saline. Blood and tissue were collected up to 2 h after dosing. Fetal to maternal plasma AUC ratios were 0.09, 0.07, and 0.16 after the 1, 10, or 40 mg/kg dose, respectively. Extraplasma AUCs were greatest in maternal kidney and uterus and lowest in maternal and fetal brain. A greater than fourfold elevation in fetal AUC was found when the dose was increased from 10 to 40 mg/kg, suggesting saturation of maternal plasma binding of 2,4-D. Although the in vitro fetal brain tissue to incubation media ratio was unity (1.03 +/- 0.1, mean +/- SD), fetal brain AUCs were 10% or less of the fetal plasma AUCs, indicating the brain barrier system to 2,4-D is functioning in the late-gestation fetal rabbit. However, its development may not be complete due to the higher brain tissue to plasma ratios in the fetus compared to the dam.

Citations

May 19, 2018·The Journal of Physiology·Norman R SaundersMark D Habgood
Aug 20, 2002·Critical Reviews in Toxicology·David H Garabrant, Martin A Philbert
Apr 27, 2020·Prenatal Diagnosis·Norman R Saunders, Katarzyna M Dziegielewska
Feb 27, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·J M CharlesJ S Bus

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