Distribution of 99mTc-labeled lymphocytes in control and inflamed rats

Nuclear Medicine and Biology
Alessandro FulgenziMaria Elena Ferrero

Abstract

We studied the in vivo fate of CD8(+) lymphocytes, of naive (CD8(+)CD45RC(bright)) or memory (CD8(+)CD45RC(dim)) phenotype, injected in syngeneic rats, after their sorting and labeling with [(99m)Tc] HM-PAO. By using the scintigrafic method we showed that memory CD8(+) lymphocytes were able to recirculate into liver and lungs. The same method was also successfully used to in vivo study the homing of total blood lymphocytes obtained from inflamed rats.

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Citations

Dec 7, 2011·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Michael M Graham
Nov 14, 2007·Nuclear Medicine and Biology·Formijn J van HemertRoelof J Bennink
Nov 30, 2006·Immunology Letters·Katrin S Blum, Reinhard Pabst
Sep 22, 2018·Chembiochem : a European Journal of Chemical Biology·Hye Jin LeeWeibo Cai

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