Distribution of allelic and genotypic frequencies of IL1A, IL4, NFKB1 and PAR1 variants in Native American, African, European and Brazilian populations

BMC Research Notes
Marcos Antônio Trindade AmadorSidney Santos

Abstract

The inflammatory response plays a key role at different stages of cancer development. Allelic variants of the interleukin 1A (IL1A), interleukin 4 (IL4), nuclear factor kappa B1 (NFKB1) and protease-activated receptor 1 (PAR1) genes may influence not only the inflammatory response but also susceptibility to cancer development. Among major ethnic or continental groups, these polymorphic variants present different allelic frequencies. In admixed populations, such as the Brazilian population, data on distribution of these polymorphisms are limited. Here, we collected samples of cancer-free individuals from the north, northeast, midwest, south and southeast regions of Brazil and from the three main groups that gave rise to the Brazilian population: Native Americans from the Brazilian Amazon, Africans and Europeans. We describe the allelic distributions of four IL1A (rs3783553), IL4 (rs79071878), NFKB1 (rs28362491) and PAR1 (rs11267092) gene polymorphisms, which the literature describes as polymorphisms with a risk of cancer or worse prognosis for cancer. The genotypic distribution of the four polymorphisms was statistically distinct between Native Americans, Africans and Europeans. For the allelic frequency of these polymorphisms, ...Continue Reading

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Citations

Jan 14, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Katarzyna Bogunia-KubikJerzy Świerkot
Jan 24, 2018·World Journal of Gastroenterology : WJG·Giovanna C CavalcanteSidney Santos
Dec 1, 2017·BMC Research Notes·Ellen Moreno da SilvaNey Pereira Carneiro Dos Santos
Feb 2, 2018·Medical Oncology·Larysse Maira Campos-VerdesBenedito Borges da Silva
Dec 14, 2017·Arquivos de neuro-psiquiatria·Leslie Ecker FerreiraNorberto Luiz Cabral
Sep 21, 2018·Frontiers in Oncology·Thomas M DrakeKjetil Søreide
Oct 21, 2020·BMC Medical Genetics·Giovanna Chaves CavalcanteÂndrea Ribeiro-Dos-Santos
Jun 3, 2021·International Journal of Molecular Sciences·Aditi Kothari, Matthew J Flick

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

Arlequin
GeneMapper
BioEstat
R

Related Concepts

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Cancer Disparities

Cancer disparities refers to differences in cancer outcomes (e.g., number of cancer cases, related health complications) across population groups.