PMID: 9191103Jun 1, 1997Paper

Distribution of AMPA receptor subunit mRNAs in the human basal ganglia: an in situ hybridization study

Brain Research. Molecular Brain Research
M TomiyamaGuadalupe Mengod

Abstract

The distribution of AMPA receptor subunit mRNAs (spliced flip and flop variants of GluR-A to GluR-D) in the human post-mortem striatum, nucleus accumbens, globus pallidus and basal nucleus of Meynert was determined by in situ hybridization histochemistry. In the striatum and nucleus accumbens, for each subunit, the mRNA for the flop variant was more enriched than that for the corresponding flip variant. The GluR-C(flop) mRNA was most abundant, followed by the GluR-A(flop) mRNA. Transcripts for flop forms were evenly distributed in these regions, whereas those for flip forms showed a dorsoventral increasing gradient of the hybridization signals. The signals in these areas were found to originate mainly from medium-sized neurons. In the globus pallidus, mRNAs encoding GluR-A(flop) and GluR-C(flop) were also abundantly expressed. The basal nucleus of Meynert was enriched for mRNAs of flop forms. In conclusion, AMPA receptors in these areas of the human basal ganglia appeared to be mainly composed of flop variants, especially GluR-A(flop) and GluR-C(flop). However, the finding that flip transcripts were more abundant in the nucleus accumbens than in the striatum implies differences in functions of AMPA receptors between the two reg...Continue Reading

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Citations

Nov 22, 2000·Brain Research. Brain Research Reviews·F CicchettiA Parent
Jul 27, 2001·Journal of Chemical Neuroanatomy·Y SmithA I Levey
Jan 1, 2013·Journal of Chemical Neuroanatomy·Cristina SanabraGuadalupe Mengod
Dec 21, 2006·The Journal of Comparative Neurology·P PifarréG Mengod
Aug 14, 2008·The Journal of Comparative Neurology·Laura Saenz del BurgoJoan Salles
Nov 22, 2000·Experimental Neurology·M D IkonomovicD M Armstrong
Jan 18, 2005·Journal of Chemical Neuroanatomy·Jordi SerratsRoser Cortés
Oct 6, 2007·Journal of Neuropathology and Experimental Neurology·Elisabet Reyes-IrisarriGuadalupe Mengod

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