Distribution of an intravenous injectable nimodipine nanosuspension in mice

The Journal of Pharmacy and Pharmacology
Ruolan XiongPeiquan Wang

Abstract

The distribution of an intravenous injectable nimodipine nanosuspension with mean particle size of both 300 and 650 nm in mice was systemically investigated compared with that of a nimodipine ethanol formulation (Nimotop) and a nanosuspension coated with Tween-80. The results showed that the 650-nm nanoparticles provided significantly higher drug concentrations in the liver, spleen and lungs because of their capture by Kupffer cells in the mononuclear phagocyte system, but lower drug concentrations in the brain compared with Nimotop and smaller nanoparticles. These nanoparticles failed to give increased brain concentrations even when coated with Tween-80. The 300-nm nanoparticles could effectively increase drug concentrations in the brain and remarkably reduce drug concentrations in the liver, spleen and lungs, indicating that the nimodipine nanosuspension may be a promising formulation with no ethanol, but the particle size must be small.

References

Jan 1, 1986·European Journal of Clinical Pharmacology·E VingeS Rosendal-Helgesen
Jul 1, 1993·Journal of Pharmaceutical Sciences·J Yuan
Feb 19, 1998·Journal of Biomedical Materials Research·M LückR H Müller
Mar 17, 2001·Advanced Drug Delivery Reviews·J Kreuter
Oct 9, 2007·International Journal of Pharmaceutics·Ruolan XiongTingting Chen

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Citations

Nov 21, 2015·Archives of Pharmacal Research·Jianwen LiYongjun Wang
Aug 3, 2010·International Journal of Pharmaceutics·Ranjita Shegokar, Rainer H Müller
Oct 14, 2010·Molecular Membrane Biology·Ranendra N SahaMovva Snehalatha

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