PMID: 8950025Nov 1, 1996Paper

Distribution of and age-related changes in ciliary neurotrophic factor protein in rat tissues

Biochemistry and Molecular Biology International
M OhtaK Ohta

Abstract

We developed a sensitive enzyme-linked immunosolvent assay for measuring ciliary neurotrophic factor (CNTF) and examined age-related changes in the CNTF contents of a variety of rat tissues during postnatal development. CNTF contents were substantially higher in the sciatic nerve and spinal cord than in the other tissues tested, the kidney coming third. In all the tissues except the sciatic nerve (90 ng/g), the CNTF content was less than 1 ng/g at 1 week of age, then gradually increased. It was highest at 5 weeks of age in the sciatic nerve (3171 ng/g), spinal cord (118 ng/g), and kidney (36.8 ng/g), after which it slowly decreased. In contrast, the maximum in the brain stem (9 ng/g) and cerebellum (3.6 ng/g) was at 8 weeks of age, whereas in skeletal muscle it was at 2 weeks of age (14.6 ng/g). These findings indicate that CNTF functions in the postnatal development of the rat.

Citations

Jul 5, 2013·PloS One·Cristina Nogueira-SilvaJorge Correia-Pinto
Dec 18, 2018·Frontiers in Physiology·Su YangXiao-Jiang Li

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