PMID: 2113279Mar 1, 1990Paper

Distribution of angiotensin II receptors in the brain of nonhuman primates

Peptides
M A MillanG Aguilera

Abstract

Angiotensin II binding sites were demonstrated at discrete nuclei in the brain of three nonhuman primate species by autoradiography, using the agonist ligand, [Sar1]AII. Although there were some differences in location of the binding sites, all three species exhibited a characteristic pattern of distribution in areas related to water intake, vasopressin secretion, and blood pressure regulation through modulation of sympathetic activity. Studies in the cynomolgus monkey with the antagonist ligand, [Sar1,Ile8]AII, which localizes in pathways as well as nuclei, revealed novel regions of binding including the habenular-interpeduncular pathway, ventral bundle, and XII nerve, in addition to the X nerve. These data indicated that AII, as in other species, has a role in the central homeostatic control mechanisms in the primate.

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Citations

Dec 24, 2004·Neurotoxicity Research·David M Jacobowitz
Dec 24, 2004·Neurotoxicity Research·Jay Schulkin
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·J W Wright, J W Harding
Sep 1, 1992·Brain Research. Brain Research Reviews·J W Wright, J W Harding
Nov 10, 1995·Regulatory Peptides·J W Wright, J W Harding
Nov 25, 1997·Brain Research. Brain Research Reviews·J W Wright, J W Harding
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M A MillanK J Catt
Dec 29, 1995·Annals of the New York Academy of Sciences·G AguileraB S Akbasak
Sep 30, 1991·Biochemical and Biophysical Research Communications·C BergwitzH Jüppner
Jun 11, 2020·Genetics and Molecular Biology·Fam Bibiana S OMaria Cátira Bortolini
Mar 27, 1995·Brain Research·D P MacGregorF A Mendelsohn

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