PMID: 6164035Jan 1, 1981Paper

Distribution of anionic groups in the glomerular capillary wall in rat nephrotoxic nephritis and aminonucleoside nephrosis

Pathology
D Alcorn, G B Ryan

Abstract

It is widely believed that polyanionic plasma proteins, such as albumin, are normally prevented from penetrating the glomerular capillary wall by the presence of intrinsic fixed negative charges in the wall. There is also strong support for the corollary that proteinuria occurs in glomerular disease as a result of loss of such charges. Morphologic studies using cationic 'stains' have indicated that anionic groups can be detected in normal glomeruli and that, in proteinuric states, there is an apparent reduction in such staining. Because most of the latter claims are based largely upon light microscopic studies, critical reassessment at the electron microscopic level is necessary, particularly using the recently developed technique of in situ drip-fixation of superficial glomeruli during good blood flow. In normal rats, this technique results in heavy cationic colloidal iron staining of podocytic epithelial surfaces but little or no staining in the basement membrane or within endothelial fenestrae. In two experimental proteinuric models, rat nephrotoxic nephritis and aminonucleoside nephrosis, there was no loss of colloidal iron staining on podocytic epithelial surfaces at any stage. There was, however, a striking alteration in ...Continue Reading

References

Jun 1, 1975·Journal of Ultrastructure Research·H LattaT M Stanley
Sep 1, 1979·Kidney International·W M DeenB M Brenner
Sep 1, 1979·Kidney International·J N PurtellV E Pollak
Dec 1, 1978·Journal of Ultrastructure Research·G B RyanM J Karnovsky
Jan 1, 1977·Kidney International·H G Rennke, M A Venkatachalam
Jul 1, 1977·The Journal of Clinical Investigation·M P BohrerW T Willis
Oct 1, 1976·Journal of Ultrastructure Research·H Latta, W H Johnston
Oct 1, 1975·Kidney International·G B Ryan, M J Karnovsky
Dec 1, 1975·The Journal of Cell Biology·H G RennkeM A Venkatachalam
Nov 1, 1974·The Journal of Clinical Investigation·A M RobsonJ R Ingelfinger
Dec 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·L P RoyA F Michael
Mar 1, 1969·The Journal of Cell Biology·J GroniowskiM Walski
Jun 27, 1969·Science·S C Mohos, L Skoza
Jan 1, 1959·The Journal of Experimental Medicine·R L VERNIERR A GOOD
Jan 1, 1964·Biophysical Journal·A KATCHALSKY

❮ Previous
Next ❯

Citations

Jun 13, 1981·Lancet
May 1, 1994·The Journal of Pathology·M D al-Nawab, D R Davies
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·J Quatacker
Jan 1, 1985·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·D J Bliss, D B Brewer
Nov 1, 1983·Kidney International·T CavalloP H Lambert
Aug 30, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin M BennettAlan P Koretsky
Jul 1, 1985·Pathology·D J DaviesG B Ryan
Aug 1, 1983·Bioscience Reports·M Rand-Weaver, R G Price
Jul 17, 1999·The American Journal of Physiology·T M OsickaW D Comper
Jan 1, 1991·Annals of Clinical Biochemistry·T Ozben

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.