Distribution of Anti-Factor Xa Activity in Patients on Edoxaban Therapy for Non-Valvular Atrial Fibrillation

Circulation Journal : Official Journal of the Japanese Circulation Society
Hiroyuki OsanaiKazuyoshi Sakai

Abstract

The distribution of anti-factor Xa activity (AXA) values in non-valvular atrial fibrillation (NVAF) patients on edoxaban therapy has not been fully elucidated. The steady-state trough and peak AXA values were measured in 66 NVAF patients. The trough AXA value did not differ significantly between the 60-mg and the 30-mg OD groups (0.17±0.13 IU/ml vs. 0.12±0.11 IU/ml, respectively; P=0.17). Similarly, the peak AXA value did not differ significantly between the 2 groups (1.45±0.81 IU/ml vs. 1.25±0.48 IU/ml, respectively; P=0.26). Recommended dosing should be followed for sufficient efficacy of edoxaban. (Circ J 2016; 80: 745-747).

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jun 6, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi YamashitaSatoshi Ogawa
Jun 15, 2013·Thrombosis and Haemostasis·Jonathan DouxfilsFrançois Mullier
Nov 21, 2013·The New England Journal of Medicine·Robert P GiuglianoUNKNOWN ENGAGE AF-TIMI 48 Investigators
Jun 27, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Jul 19, 2014·Drugs·Henri Bounameaux, A John Camm
Sep 13, 2014·Journal of the American College of Cardiology·Adam CukerDavid A Garcia
Feb 12, 2015·Journal of Thrombosis and Thrombolysis·Adam Cuker, Holleh Husseinzadeh
Oct 7, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroyuki OsanaiKazuyoshi Sakai

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Circulation Journal : Official Journal of the Japanese Circulation Society
Hiroyuki OsanaiKazuyoshi Sakai
The British Journal of General Practice : the Journal of the Royal College of General Practitioners
E Roderick, J Cox
Circulation Journal : Official Journal of the Japanese Circulation Society
Vanessa RoldánGregory Y H Lip
Circulation Journal : Official Journal of the Japanese Circulation Society
Takeshi YamashitaSatoshi Ogawa
© 2021 Meta ULC. All rights reserved