PMID: 6162791Jan 1, 1981Paper

Distribution of antigenic determinants recognized by three monoclonal antibodies (Q2/70, Q5/6 and Q5/13) on human Ia-like alloantigens and on their subunits

Immunogenetics
V QuarantaS Ferrone

Abstract

The distribution of antigenic determinants recognized by the anti-Ia-like antigen monoclonal antibodies (MoAb) Q2/70, Q5/6 and Q5/13 on molecules coded for by the DR locus and by non-DR loci was investigated using a binding assay with 125I-labeled Ia-like antigens isolated from four B lymphoid cell lines. The determinants reacting with the MoAb Q2/70 and Q5/13 are expressed on all DR alloantigens tested and on BR4X7 specificities, while those reacting with the MoAb Q5/6 are not detectable on DRw7 and BR4X7 molecules. None of the monoclonal antibodies reacted with DC1 molecules. The MoAb Q5/6 and Q5/13 reacted with the isolated beta subunit of the Ia-like antigenic complex, while the MoAb Q2/70 did not react with the isolated chains.

References

Jan 1, 1977·Scandinavian Journal of Immunology·J J van RoodA Termijtelen
Dec 1, 1978·The Journal of Experimental Medicine·R TosiD Pressman
Jan 1, 1979·Immunological Reviews·F M BrodskyW F Bodmer
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J P AllisonJ Silver
Jan 1, 1979·Molecular Immunology·J SilverS Ferrone
Jan 1, 1971·Transplantation Reviews·J Klein, D C Shreffler
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
May 1, 1981·Molecular Immunology·S CarrelR S Accolla
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R S AccollaG Corte
Dec 1, 1980·Molecular Immunology·L E WalkerR A Reisfeld
May 31, 1979·Nature·J Silver, S Ferrone

❮ Previous
Next ❯

Citations

Jan 1, 1987·Archives of Dermatological Research·W Aberer, H Leibl
Feb 24, 1984·Journal of Immunological Methods·W S WalkerS E Yen
Nov 15, 1989·Veterinary Immunology and Immunopathology·A M Janzer-Pfeil, G A Splitter
Feb 1, 1983·Human Immunology·A ZeeviR J Duquesnoy
Mar 1, 1983·Human Immunology·C H ThompsonI F McKenzie
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A ZeeviR J Duquesnoy
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J MoriuchiJ Silver
Mar 3, 2011·PloS One·Norbert KochSebastian Springer
Jan 1, 1982·Immunological Reviews·E ThorsbyH Nousiainen

❮ Previous
Next ❯

Related Concepts

Related Feeds