Distribution of APOE genotypes in a memory clinic cohort

Dementia and Geriatric Cognitive Disorders
Wiesje M van der FlierPhilip Scheltens

Abstract

To describe the distribution of apolipoprotein E (APOE) genotypes in a cohort of memory clinic patients. We included 749 memory clinic patients. Diagnoses were made in a multidisciplinary consensus meeting and the APOE genotype was determined. The community-based cohort of the Longitudinal Aging Study Amsterdam was used as control population (n = 2,233). In the memory clinic sample, there were 173 patients with subjective complaints, 125 patients with mild cognitive impairment (MCI), 251 patients with Alzheimer disease (AD), 107 patients with another type of dementia, and 93 patients with another neurologic or psychiatric diagnosis. The APOE allele distribution differed among groups. There was no difference in the prevalence of the epsilon2 allele, but there were differences in distribution of the epsilon3 and epsilon4 alleles. Compared with the control population (15%), the prevalence of APOE epsilon4 was increased among patients with subjective complaints (22%), MCI (36%), AD (42%) and other types of dementia (25%). We observed an increased prevalence of APOE epsilon4 in patients with MCI and subjective complaints. This finding is of great clinical importance as nondemented patients positive for APOE epsilon4 could be identif...Continue Reading

Citations

Feb 26, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Roberto GallassiLuisa Sambati
Apr 4, 2014·Age·Jaqueline B SchuchFabiana M de Andrade
Jun 16, 2012·International Journal of Geriatric Psychiatry·Mayumi NoseTakashi Asada
May 7, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Frank JessenUNKNOWN Subjective Cognitive Decline Initiative (SCD-I) Working Group
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Octavio Rodríguez-GómezMerçé Boada
Sep 11, 2014·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Nicolas CherbuinKaarin J Anstey
Mar 19, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Guro BergeLinda R White
Sep 29, 2011·Dementia and Geriatric Cognitive Disorders·J NorbergP J Visser
Dec 5, 2009·Aging Clinical and Experimental Research·Samantha GalluzziGiovanni B Frisoni
Mar 9, 2017·Journal of Alzheimer's Disease : JAD·Carla AbdelnourMercè Boada
Mar 12, 2020·Frontiers in Aging Neuroscience·Chia-Hsiung ChengPei-Ning Wang
Mar 23, 2018·Journal of Alzheimer's Disease : JAD·Wiesje M van der Flier, Philip Scheltens
Jul 1, 2020·Neurobiology of Aging·Brian J LoprestiDana L Tudorascu
Jan 31, 2020·Ageing Research Reviews·Richard D SembaLuigi Ferrucci
Jul 3, 2021·International Journal of Environmental Research and Public Health·Veruscka LesoIvo Iavicoli

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