PMID: 8581561Sep 1, 1995Paper

Distribution of beta amyloid associated proteins in plaques in Alzheimer's disease and in the non-demented elderly

Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration
S S ZhanP Eikelenboom

Abstract

Recent studies have shown that cerebral beta amyloid (A beta) protein deposition is a necessary, but not sufficient, factor to develop the pathology of Alzheimer's disease (AD). In the present immunohistochemical study, we have investigated in AD the distribution of A beta associated proteins in the cerebral neocortex, in the cerebellar cortex where A beta plaques are mainly of the diffuse type, and also in the cerebral neocortex of non-demented patients with A beta plaques. Results show that immunolabeling for C1q, C4c, C3d, alpha 1-ACT and Apolipoprotein E (ApoE) occurs in the great majority of A beta plaques in all groups. ApoJ is present in A beta plaques of the cerebral neocortex in AD and in non-demented elderly, but is almost absent from those of the AD cerebellar cortex. C4Bp and P-component, in contrast to AD, rarely occurs in A beta plaques of the cerebral neocortex in the non-demented elderly. Heparan sulphate proteoglycan (HSPG) core protein and intercellular adhesion molecule-1 (ICAM-1) are absent in the diffuse A beta plaques in the AD cerebellum. These differences in distribution and expression of A beta associated proteins may be determined by brain region specific factors (cerebral cortex versus cerebellar cort...Continue Reading

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Citations

May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Joo-Yong LeeJae-Young Koh
May 7, 2011·Molecular Immunology·Robert VeerhuisAndrea J Tenner
Apr 12, 2007·Expert Review of Proteomics·Simon LovestoneMalcolm Ward
Apr 28, 2010·Expert Review of Neurotherapeutics·Siddhartha Mondragón-RodríguezMark A Smith
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Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Wesley JongbloedRobert Veerhuis
Dec 14, 1999·The American Journal of Pathology·M M VerbeekR M de Waal
Aug 5, 1999·Experimental Gerontology·P Eikelenboom, R Veerhuis
Jun 13, 2000·Alzheimer Disease and Associated Disorders·P EikelenboomW A van Gool
Aug 5, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Pavitra KannanJan Mulder
Jan 21, 2012·Neuro-degenerative Diseases·Piet EikelenboomJeroen J M Hoozemans
Dec 3, 2017·The Journal of Cell Biology·David V HansenMorgan Sheng
Oct 13, 2006·Journal of Neural Transmission·P EikelenboomJ J M Hoozemans
Jul 5, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·J J HoozemansP Eikelenboom
Nov 5, 1997·Biological Chemistry·M M VerbeekR M de Waal
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Oct 23, 2013·Annals of Clinical Biochemistry·Wesley JongbloedRobert Veerhuis
May 16, 2002·Neurobiology of Aging·Jack van HorssenMarcel M Verbeek
May 11, 2021·Frontiers in Aging Neuroscience·Lars MichelsAnton Gietl
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Sep 1, 1996·Neurobiology of Aging·P Eikelenboom, R Veerhuis
Jun 17, 2008·Molecular Immunology·Leendert A TrouwAnna M Blom

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